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Authors: Lagrange, Jeremy
Wagner, Bianca
Nagler, Markus
ten Cate, Vincent
Pallares Robles, Alejandro
Koeck, Thomas
Rapp, Steffen
Prochaska, Jürgen H.
Spronk, Henri M.
Wenzel, Philip
Ruf, Wolfram
ten Cate, Hugo
Wild, Philipp S.
Panova-Noeva, Marina
Title: Characterization of thrombin generation curve shape in presence of platelets from acute venous thromboembolism patients
Online publication date: 18-Dec-2020
Language: english
Abstract: Background. Anticoagulant therapy, the cornerstone treatment in acute venous thromboembolism (VTE), strongly impacts thrombin generation (TG). Until now, the appearance of the TG curve in platelet rich plasma (PRP) from patients with acute VTE has not been investigated. Methods. We analyzed the shape of TG curves measured in PARP of 180 acute VTE patients. Results. Normal shape of TG curves was observed in 110 patients, 50 patients showed no TG and 20 patients showed biphasic TG curve. The linear regression analysis, adjusted for age, sex, VTE clinical phenotypes and therapy showed that the appearance of biphasic curves is significantly associated with female sex, presence of cancer and therapy with Factor Xa inhibitors. Conclusions. This study demonstrated that despite taking anticoagulants, TG in presence of platelets is still present in the majority of acute VTE patients. Appearance of unusual TG curves is strongly related to the intake of anti-Factor Xa inhibitors. The clinical relevance of biphasic TG curve appearance requires further investigation. Keywords: thrombin generation venous thromboembolism platelets factor Xa inhibitor
DDC: 610 Medizin
610 Medical sciences
Institution: Johannes Gutenberg-Universität Mainz
Department: FB 04 Medizin
Place: Mainz
Version: Published version
Publication type: Zeitschriftenaufsatz
Document type specification: Scientific article
License: CC BY
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Journal: Journal of Clinical Medicine
Pages or article number: 2892
Publisher: MDPI
Publisher place: Basel
Issue date: 2020
ISSN: 2077-0383
Publisher URL:
Publisher DOI: 10.3390/jcm9092892
Appears in collections:JGU-Publikationen

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