Characterization of thrombin generation curve shape in presence of platelets from acute venous thromboembolism patients

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dc.contributor.authorLagrange, Jeremy
dc.contributor.authorWagner, Bianca
dc.contributor.authorNagler, Markus
dc.contributor.authorten Cate, Vincent
dc.contributor.authorPallares Robles, Alejandro
dc.contributor.authorKoeck, Thomas
dc.contributor.authorRapp, Steffen
dc.contributor.authorProchaska, Jürgen H.
dc.contributor.authorSpronk, Henri M.
dc.contributor.authorWenzel, Philip
dc.contributor.authorRuf, Wolfram
dc.contributor.authorten Cate, Hugo
dc.contributor.authorWild, Philipp S.
dc.contributor.authorPanova-Noeva, Marina
dc.date.accessioned2020-12-18T09:18:22Z
dc.date.available2020-12-18T09:18:22Z
dc.date.issued2020
dc.description.abstractBackground. Anticoagulant therapy, the cornerstone treatment in acute venous thromboembolism (VTE), strongly impacts thrombin generation (TG). Until now, the appearance of the TG curve in platelet rich plasma (PRP) from patients with acute VTE has not been investigated. Methods. We analyzed the shape of TG curves measured in PARP of 180 acute VTE patients. Results. Normal shape of TG curves was observed in 110 patients, 50 patients showed no TG and 20 patients showed biphasic TG curve. The linear regression analysis, adjusted for age, sex, VTE clinical phenotypes and therapy showed that the appearance of biphasic curves is significantly associated with female sex, presence of cancer and therapy with Factor Xa inhibitors. Conclusions. This study demonstrated that despite taking anticoagulants, TG in presence of platelets is still present in the majority of acute VTE patients. Appearance of unusual TG curves is strongly related to the intake of anti-Factor Xa inhibitors. The clinical relevance of biphasic TG curve appearance requires further investigation. Keywords: thrombin generation venous thromboembolism platelets factor Xa inhibitoren_GB
dc.description.sponsorshipDFG, Open Access-Publizieren Universität Mainz / Universitätsmedizin Mainzde
dc.identifier.doihttp://doi.org/10.25358/openscience-5508
dc.identifier.urihttps://openscience.ub.uni-mainz.de/handle/20.500.12030/5512
dc.language.isoengde
dc.rightsCC-BY-4.0de_DE
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subject.ddc610 Medizinde_DE
dc.subject.ddc610 Medical sciencesen_GB
dc.titleCharacterization of thrombin generation curve shape in presence of platelets from acute venous thromboembolism patientsen_GB
dc.typeZeitschriftenaufsatzde
jgu.journal.issue9de
jgu.journal.titleJournal of Clinical Medicinede
jgu.journal.volume9de
jgu.organisation.departmentFB 04 Medizinde
jgu.organisation.nameJohannes Gutenberg-Universität Mainz
jgu.organisation.number2700
jgu.organisation.placeMainz
jgu.organisation.rorhttps://ror.org/023b0x485
jgu.pages.alternative2892de
jgu.publisher.doi10.3390/jcm9092892
jgu.publisher.issn2077-0383de
jgu.publisher.nameMDPIde
jgu.publisher.placeBaselde
jgu.publisher.urihttps://doi.org/10.3390/jcm9092892de
jgu.publisher.year2020
jgu.rights.accessrightsopenAccess
jgu.subject.ddccode610de
jgu.type.contenttypeScientific articlede
jgu.type.dinitypeArticleen_GB
jgu.type.resourceTextde
jgu.type.versionPublished versionde

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