Gutenberg Open Science: Wheat consumption leads to immune activation and symptom worsening in patients with familial mediterranean fever : a pilot randomized trial

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-5228

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DC Field	Value	Language
dc.contributor.author	Carroccio, Antonio	-
dc.contributor.author	Mansueto, Pasquale	-
dc.contributor.author	Soresi, Maurizio	-
dc.contributor.author	Fayer, Francesca	-
dc.contributor.author	Di Liberto, Diana	-
dc.contributor.author	Monguzzi, Erika	-
dc.contributor.author	Lo Pizzo, Marianna	-
dc.contributor.author	La Blasca, Francesco	-
dc.contributor.author	Geraci, Girolamo	-
dc.contributor.author	Pecoraro, Alice	-
dc.contributor.author	Dieli, Francesco	-
dc.contributor.author	Schuppan, Detlef	-
dc.date.accessioned	2020-10-26T08:40:01Z	-
dc.date.available	2020-10-26T08:40:01Z	-
dc.date.issued	2020	-
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/5232	-
dc.description.abstract	We have identified a clinical association between self-reported non-celiac wheat sensitivity (NCWS) and Familial Mediterranean Fever (FMF). Objectives: A) To determine whether a 2-week double-blind placebo-controlled (DBPC) cross-over wheat vs. rice challenge exacerbates the clinical manifestations of FMF; B) to evaluate innate immune responses in NCWS/FMF patients challenged with wheat vs. rice. The study was conducted at the Department of Internal Medicine of the University Hospital of Palermo and the Hospital of Sciacca, Italy. Six female volunteers with FMF/NCWS (mean age 36 ± 6 years) were enrolled, 12 age-matched non-FMF, NCWS females, and 8 sex- and age-matched healthy subjects served as controls. We evaluated: 1. clinical symptoms by the FMF-specific AIDAI (Auto-Inflammatory Diseases Activity Index) score; 2. serum soluble CD14 (sCD14), C-reactive protein (CRP), and serum amyloid A (SSA); 3. circulating CD14+ monocytes expressing interleukin (IL)-1β and tumor necrosis factor (TNF)-α. The AIDAI score significantly increased in FMF patients during DBPC with wheat, but not with rice (19 ± 6.3 vs. 7 ± 1.6; p = 0.028). sCD14 values did not differ in FMF patients before and after the challenge, but were higher in FMF patients than in healthy controls (median values 11357 vs. 8710 pg/ml; p = 0.002). The percentage of circulating CD14+/IL-1β+ and of CD14+/TNF-α+ monocytes increased significantly after DBPC with wheat vs. baseline or rice challenge. Self-reported NCWS can hide an FMF diagnosis. Wheat ingestion exacerbated clinical and immunological features of FMF. Future studies performed on consecutive FMF patients recruited in centers for auto-inflammatory diseases will determine the real frequency and relevance of this association.	en_GB
dc.description.sponsorship	DFG, Open Access-Publizieren Universität Mainz / Universitätsmedizin	de
dc.language.iso	eng	de
dc.rights	CC BY	-
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	-
dc.subject.ddc	610 Medizin	de_DE
dc.subject.ddc	610 Medical sciences	en_GB
dc.title	Wheat consumption leads to immune activation and symptom worsening in patients with familial mediterranean fever : a pilot randomized trial	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-5228	-
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 04 Medizin	de
jgu.organisation.number	2700	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	Nutrients	de
jgu.journal.volume	12	de
jgu.journal.issue	4	de
jgu.pages.alternative	Art. 1127	de
jgu.publisher.year	2020	-
jgu.publisher.name	MDPI	de
jgu.publisher.place	Basel	de
jgu.publisher.uri	https://doi.org/10.3390/nu12041127	de
jgu.publisher.issn	2072-6643	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	610	de
jgu.publisher.doi	10.3390/nu12041127
jgu.organisation.ror	https://ror.org/023b0x485
Appears in collections:	JGU-Publikationen

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