Please use this identifier to cite or link to this item:
http://doi.org/10.25358/openscience-5225
Authors: | Man, Andy W. C. Zhou, Yawen Xia, Ning Li, Huige |
Title: | Perivascular adipose tissue as a target for antioxidant therapy for cardiovascular complications |
Online publication date: | 23-Oct-2020 |
Year of first publication: | 2020 |
Language: | english |
Abstract: | Abstract: Perivascular adipose tissue (PVAT) is the connective tissue surrounding most of the systemic blood vessels. PVAT is now recognized as an important endocrine tissue that maintains vascular homeostasis. Healthy PVAT has anticontractile, anti-inflammatory, and antioxidative roles. Vascular oxidative stress is an important pathophysiological event in cardiometabolic complications of obesity, type 2 diabetes, and hypertension. Accumulating data from both humans and experimental animal models suggests that PVAT dysfunction is potentially linked to cardiovascular diseases, and associated with augmented vascular inflammation, oxidative stress, and arterial remodeling. Reactive oxygen species produced from PVAT can be originated from mitochondria, nicotinamide adenine dinucleotide phosphate (NADPH) oxidases, and uncoupled endothelial nitric oxide synthase. PVAT can also sense vascular paracrine signals and response by secreting vasoactive adipokines. Therefore, PVAT may constitute a novel therapeutic target for the prevention and treatment of cardiovascular diseases. In this review, we summarize recent findings on PVAT functions, ROS production, and oxidative stress in different pathophysiological settings and discuss the potential antioxidant therapies for cardiovascular diseases by targeting PVAT. |
DDC: | 610 Medizin 610 Medical sciences |
Institution: | Johannes Gutenberg-Universität Mainz |
Department: | FB 04 Medizin |
Place: | Mainz |
ROR: | https://ror.org/023b0x485 |
DOI: | http://doi.org/10.25358/openscience-5225 |
Version: | Published version |
Publication type: | Zeitschriftenaufsatz |
License: | CC BY |
Information on rights of use: | https://creativecommons.org/licenses/by/4.0/ |
Journal: | Antioxidants 9 7 |
Pages or article number: | 574 |
Publisher: | MDPI |
Publisher place: | Basel |
Issue date: | 2020 |
Publisher URL: | https://doi.org/10.3390/antiox9070574 |
Publisher DOI: | 10.3390/antiox9070574 |
Appears in collections: | JGU-Publikationen |
Files in This Item:
File | Description | Size | Format | ||
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li_huige-perivascular_a-20201016152120187.pdf | 1.51 MB | Adobe PDF | View/Open |