Authors:	Belikan, Patrick Nauth, Lisa Färber, Lars-Christopher Abel, Frédéric Langendorf, Eva Drees, Philipp Rommens, Pol M. Ritz, Ulrike Mattyasovszky, Stefan G.
Title:	Intramuscular injection of combined calf blood compound (CFC) and homeopathic drug Tr14 accelerates muscle regeneration in vivo
Online publication date:	28-Aug-2020
Year of first publication:	2020
Language:	english
Abstract:	Skeletal muscle injuries in competitive sports cause lengthy absences of athletes from tournaments. This is of tremendous competitive and economic relevance for both the athletes and their respective clubs. Therapy for structural muscle lesions aims to promote regeneration and fast-track return-to-play. A common clinical treatment strategy for muscle injuries is the intramuscular injection of calf blood compound and the homeopathic drug, Tr14. Although the combination of these two agents was reported to reduce recovery time, the regulatory mechanism whereby this occurs remains unknown. In this in vivo study, we selected a rat model of mechanical muscle injury to investigate the effect of this combination therapy on muscle regeneration. Gene expression analysis and histological images revealed that this combined intramuscular injection for muscle lesions can enhance the expression of pro-myogenic genes and proteins and accelerate muscle regeneration. These findings are novel and depict the positive effects of calf blood compound and the homeopathic drug, Tr14, which are utilized in the field of Sports medicine. Keywords: muscle injury; calf blood compound; homeopathic drug; muscle regeneration; intramuscular injections
DDC:	570 Biowissenschaften 570 Life sciences 610 Medizin 610 Medical sciences
Institution:	Johannes Gutenberg-Universität Mainz
Department:	FB 04 Medizin
Place:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-5092
Version:	Published version
Publication type:	Zeitschriftenaufsatz
Document type specification:	Scientific article
License:	CC BY
Information on rights of use:	https://creativecommons.org/licenses/by/4.0/
Journal:	International journal of molecular sciences 21 6
Pages or article number:	2112
Publisher:	MDPI
Publisher place:	Basel
Issue date:	2020
ISSN:	1422-0067
Publisher URL:	https://doi.org/10.3390/ijms21062112
Publisher DOI:	10.3390/ijms21062112
Appears in collections:	JGU-Publikationen