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Authors: Belikan, Patrick
Nauth, Lisa
Färber, Lars-Christopher
Abel, Frédéric
Langendorf, Eva
Drees, Philipp
Rommens, Pol M.
Ritz, Ulrike
Mattyasovszky, Stefan G.
Title: Intramuscular injection of combined calf blood compound (CFC) and homeopathic drug Tr14 accelerates muscle regeneration in vivo
Online publication date: 28-Aug-2020
Language: english
Abstract: Skeletal muscle injuries in competitive sports cause lengthy absences of athletes from tournaments. This is of tremendous competitive and economic relevance for both the athletes and their respective clubs. Therapy for structural muscle lesions aims to promote regeneration and fast-track return-to-play. A common clinical treatment strategy for muscle injuries is the intramuscular injection of calf blood compound and the homeopathic drug, Tr14. Although the combination of these two agents was reported to reduce recovery time, the regulatory mechanism whereby this occurs remains unknown. In this in vivo study, we selected a rat model of mechanical muscle injury to investigate the effect of this combination therapy on muscle regeneration. Gene expression analysis and histological images revealed that this combined intramuscular injection for muscle lesions can enhance the expression of pro-myogenic genes and proteins and accelerate muscle regeneration. These findings are novel and depict the positive effects of calf blood compound and the homeopathic drug, Tr14, which are utilized in the field of Sports medicine. Keywords: muscle injury; calf blood compound; homeopathic drug; muscle regeneration; intramuscular injections
DDC: 570 Biowissenschaften
570 Life sciences
610 Medizin
610 Medical sciences
Institution: Johannes Gutenberg-Universität Mainz
Department: FB 04 Medizin
Place: Mainz
Version: Published version
Publication type: Zeitschriftenaufsatz
Document type specification: Scientific article
License: CC-BY
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Journal: International journal of molecular sciences
Pages or article number: 2112
Publisher: MDPI
Publisher place: Basel
Issue date: 2020
ISSN: 1422-0067
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Appears in collections:JGU-Publikationen

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