Authors:	Geyer, Martin Wild, Johannes Hirschmann, Marc Dimitriadis, Zisis Münzel, Thomas Gori, Tommaso Wenzel, Philip
Title:	Predictors for target vessel failure after recanalization of chronic total occlusions in patients undergoing surveillance coronary angiography
Online publication date:	10-Jun-2020
Year of first publication:	2020
Language:	english
Abstract:	(1) Background: Knowledge about predictors for the long-time patency of recanalized chronic total coronary occlusions (CTOs) is limited. Evidence from invasive follow-up in the absence of acute coronary syndrome (routine surveillance coronary angiography) is scarce. (2) Methods: In a monocentric-retrospective analysis, we obtained baseline as well as periprocedural data of patients undergoing routine invasive follow-up. We defined target vessel failure (TVF) as a combined primary endpoint, consisting of re-occlusion, restenosis, and target vessel revascularization (TVR). (3) Results: We included 93 consecutive patients (15.1% female) from October 2013 to May 2018. After a follow-up period of 206 ± 129 days (median 185 (IQR 127–237)), re-occlusion had occurred in 7.5%, restenosis in 11.8%, and TVR in 5.4%; the cumulative incidence of TVF was 15.1%. Reduced TIMI-flow immediately after recanalization (OR for TVR: 11.0 (95% CI: 2.7–45.5), p = 0.001) as well as female gender (OR for TVR: 11.0 (95% CI: 2.1–58.5), p = 0.005) were found to be predictive for pathological angiographic findings at follow-up. Furthermore, higher blood values of high-sensitive troponin after successful revascularization were associated with all endpoints. Interestingly, neither the J-CTO score nor the presence of symptoms at the follow-up visit could be correlated to adverse angiographic results. (4) Conclusions: In this medium-sized cohort of patients with surveillance coronary angiography, we were able to identify reduced TIMI flow and female gender as the strongest predictors for future TVF. Keywords: chronic total occlusion; target vessel failure; re-occlusion; surveillance coronary angiography
DDC:	610 Medizin 610 Medical sciences
Institution:	Johannes Gutenberg-Universität Mainz
Department:	FB 04 Medizin
Place:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-4878
URN:	urn:nbn:de:hebis:77-publ-598675
Version:	Published version
Publication type:	Zeitschriftenaufsatz
License:	CC BY
Information on rights of use:	https://creativecommons.org/licenses/by/4.0/
Journal:	Journal of Clinical Medicine 9 1
Pages or article number:	Art. 178
Publisher:	MDPI
Publisher place:	Basel
Issue date:	2020
ISSN:	2077-0383
Publisher URL:	http://dx.doi.org/10.3390/jcm9010178
Publisher DOI:	10.3390/jcm9010178
Appears in collections:	JGU-Publikationen