Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-378
Authors: Mier, Pablo
Andrade, Miguel
Title: Glutamine codon usage and polyQ evolution in primates depend on the Q stretch length
Online publication date: 18-May-2018
Language: english
Abstract: Amino acid usage in a proteome depends mostly on its taxonomy, as it does the codon usage in transcriptomes. Here, we explore the level of variation in the codon usage of a specific amino acid, glutamine, in relation to the number of consecutive glutamine residues. We show that CAG triplets are consistently more abundant in short glutamine homorepeats (polyQ, four to eight residues) than in shorter glutamine stretches (one to three residues), leading to the evolutionary growth of the repeat region in a CAG-dependent manner. The length of orthologous polyQ regions is mostly stable in primates, particularly the short ones. Interestingly, given a short polyQ the CAG usage is higher in unstable-in-length orthologous polyQ regions. This indicates that CAG triplets produce the necessary instability for a glutamine stretch to grow. Proteins related to polyQ-associated diseases behave in a more extreme way, with longer glutamine stretches in human and evolutionarily closer nonhuman primates, and an overall higher CAG usage. In the light of our results, we suggest an evolutionary model to explain the glutamine codon usage in polyQ regions.
DDC: 570 Biowissenschaften
570 Life sciences
Institution: Johannes Gutenberg-Universität Mainz
Department: FB 10 Biologie
Place: Mainz
DOI: http://doi.org/10.25358/openscience-378
Version: Published version
Publication type: Zeitschriftenaufsatz
License: CC BY
Information on rights of use: https://creativecommons.org/licenses/by/4.0/
Journal: Genome biology and evolution
10
3
Pages or article number: 816
825
Publisher: Oxford Univ. Press
Publisher place: Oxford
Issue date: 2018
ISSN: 1759-6653
Publisher URL: http://dx.doi.org/10.1093/gbe/evy046
Publisher DOI: 10.1093/gbe/evy046
Annotation: Andrade, Miguel veröffentlicht unter: Andrade-Navarro, Miguel A.
Appears in collections:JGU-Publikationen

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