Authors:	Foerster, Friedrich Hess, Moritz Gerhold-Ay, Aslihan Marquardt, Jens Becker, Diana Galle, Peter R. Schuppan, Detlef Binder, Harald Bockamp, Ernesto
Title:	The immune contexture of hepatocellular carcinoma predicts clinical outcome
Online publication date:	17-Oct-2018
Year of first publication:	2018
Language:	english
Abstract:	The general relevance of the immune system for cancer development and therapy is increasingly recognized. However and although the immune contexture of most human cancer types has been determined, a global characterisation of the immune tumour microenvironment in hepatocellular carcinoma (HCC) is lacking. Equally, differences in the immune contexture of HCC between different patient subgroups and its effect on survival remain to be established. Here we report an in silico analysis of the immune contexture of human HCC. Using large deep sequencing HCC tumour, adjacent non-tumour and healthy liver high-dimensional data sets, we were able to reveal previously unrecognized differences in the immune contexture of HCC. Strikingly, we found that different etiologies and HCC stages were not associated with major changes in the immune contexture. In contrast, the presence of T cells and cytotoxic cells as well as the absence of macrophages and Th2 cells positively correlated with patient survival. Based on these novel findings, we developed a prognostic score that accurately distinguishes between patients with good and poor survival. Our study provides the first global characterisation of the immune contexture of HCC and will have direct implications for future HCC therapies.
DDC:	610 Medizin 610 Medical sciences
Institution:	Johannes Gutenberg-Universität Mainz
Department:	FB 04 Medizin
Place:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-291
URN:	urn:nbn:de:hebis:77-publ-585080
Version:	Published version
Publication type:	Zeitschriftenaufsatz
License:	CC BY
Information on rights of use:	https://creativecommons.org/licenses/by/4.0/
Journal:	Scientific reports 8
Pages or article number:	Art. 85351
Publisher:	Macmillan Publishers Limited, part of Springer Nature
Publisher place:	London
Issue date:	2018
ISSN:	2045-2322
Publisher URL:	http://dx.doi.org/10.1038/s41598-018-21937-2
Publisher DOI:	10.1038/s41598-018-21937-2
Appears in collections:	JGU-Publikationen