Please use this identifier to cite or link to this item:
http://doi.org/10.25358/openscience-279
Authors: | Brüne, Daniel Andrade, Miguel Mier, Pablo |
Title: | Proteome-wide comparison between the amino acid composition of domains and linkers |
Online publication date: | 23-Jan-2019 |
Year of first publication: | 2018 |
Language: | english |
Abstract: | Objective Amino acid composition is a sequence feature that has been extensively used to characterize proteomes of many species and protein families. Yet the analysis of amino acid composition of protein domains and the linkers connecting them has received less attention. Here, we perform both a comprehensive full-proteome amino acid composition analysis and a similar analysis focusing on domains and linkers, to uncover domain- or linker-specific differential amino acid usage patterns. Results The amino acid composition in the 38 proteomes studied showcase the greater variability found in archaea and bacteria species compared to eukaryotes. When focusing on domains and linkers, we describe the preferential use of polar residues in linkers and hydrophobic residues in domains. To let any user perform this analysis on a given domain (or set of them), we developed a dedicated R script called RACCOON, which can be easily used and can provide interesting insights into the compositional differences between a domain and its surrounding linkers. |
DDC: | 570 Biowissenschaften 570 Life sciences |
Institution: | Johannes Gutenberg-Universität Mainz |
Department: | FB 10 Biologie |
Place: | Mainz |
ROR: | https://ror.org/023b0x485 |
DOI: | http://doi.org/10.25358/openscience-279 |
Version: | Published version |
Publication type: | Zeitschriftenaufsatz |
License: | CC BY |
Information on rights of use: | https://creativecommons.org/licenses/by/4.0/ |
Journal: | BMC Research Notes 11 |
Pages or article number: | Art. 117 |
Publisher: | BioMed Central |
Publisher place: | London |
Issue date: | 2018 |
ISSN: | 1756-0500 |
Publisher URL: | http://dx.doi.org/10.1186/s13104-018-3221-0 |
Publisher DOI: | 10.1186/s13104-018-3221-0 |
Annotation: | Andrade, Miguel veröffentlicht unter: Andrade-Navarro, Miguel A. |
Appears in collections: | JGU-Publikationen |