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Authors: Gonzalez-Escamilla, Gabriel
Muthuraman, Muthuraman
Chirumamilla, Venkata C.
Vogt, Johannes
Groppa, Sergiu
Title: Brain networks reorganization during maturation and healthy aging-emphases for resilience
Online publication date: 19-Dec-2018
Language: english
Abstract: Maturation and aging are important life periods that are linked to drastic brain reorganization processes which are essential for mental health. However, the development of generalized theories for delimiting physiological and pathological brain remodeling through life periods linked to healthy states and resilience on one side or mental dysfunction on the other remains a challenge. Furthermore, important processes of preservation and compensation of brain function occur continuously in the cerebral brain networks and drive physiological responses to life events. Here, we review research on brain reorganization processes across the lifespan, demonstrating brain circuits remodeling at the structural and functional level that support mental health and are parallelized by physiological trajectories during maturation and healthy aging. We show evidence that aberrations leading to mental disorders result from the specific alterations of cerebral networks and their pathological dynamics leading to distinct excitability patterns. We discuss how these series of large-scale responses of brain circuits can be viewed as protective or malfunctioning mechanisms for the maintenance of mental health and resilience.
DDC: 610 Medizin
610 Medical sciences
Institution: Johannes Gutenberg-Universität Mainz
Department: FB 04 Medizin
Place: Mainz
URN: urn:nbn:de:hebis:77-publ-587159
Version: Published version
Publication type: Zeitschriftenaufsatz
License: CC BY
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Journal: Frontiers in psychiatry
Pages or article number: Art. 601
Publisher: Frontiers Research Foundation
Publisher place: Lausanne
Issue date: 2018
ISSN: 1664-0640
Publisher URL:
Publisher DOI: 10.3389/fpsyt.2018.00601
Appears in collections:JGU-Publikationen

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