Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-252
Authors: Kuemmel, Andreas
Alflen, Astrid
Schmidt, Lars Henning
Sebastian, Martin
Wiewrodt, Rainer
Schulze, Arik Bernard
Buhl, Roland
Radsak, Markus
Title: Soluble triggering receptor expressed on myeloid cells 1 in lung cancer
Online publication date: 19-Dec-2018
Language: english
Abstract: Soluble Triggering Receptor Expressed on Myeloid Cells 1 (sTREM-1) can be found in the sera of patients with infectious, autoimmune and malignant diseases. The primary objective of this study was to investigate the prognostic significance of sTREM-1 in lung cancer patients. We analyzed the sera of 164 patients with lung cancer of all histologies and all stages at the time of diagnosis. We employed an ELISA using the anti-TREM-1 clone 6B1.1G12 mAb and recombinant human TREM-1. Patient data was collected retrospectively by chart review. In ROC-analysis, a sTREM-1 serum level of 163.1  pg/ml showed the highest Youden-Index. At this cut-off value sTREM-1 was a marker of short survival in patients with NSCLC (median survival 8.5 vs. 13.3 months, p = 0.04). A Cox regression model showed stage (p < 0.001) and sTREM-1 (p = 0.011) to indicate short survival. There were no differences in sTREM-1 serum values among patients with or without infection, pleural effusion or COPD. sTREM-1 was not associated with metastasis at the time of diagnosis and was not a predictor of subsequent metastasis. In SCLC patients sTREM-1 levels were lower than in NSCLC patients (p = 0.001) and did not predict survival. sTREM-1 did not correlate with CRP or the number of neutrophils. In non-small cell lung cancer patients, sTREM-1 in serum has prognostic significance.
DDC: 610 Medizin
610 Medical sciences
Institution: Johannes Gutenberg-Universität Mainz
Department: FB 04 Medizin
Place: Mainz
ROR: https://ror.org/023b0x485
DOI: http://doi.org/10.25358/openscience-252
Version: Published version
Publication type: Zeitschriftenaufsatz
License: CC BY
Information on rights of use: https://creativecommons.org/licenses/by/4.0/
Journal: Scientific reports
8
Pages or article number: Art. 10766
Publisher: Macmillan Publishers Limited, part of Springer Nature
Publisher place: London
Issue date: 2018
ISSN: 2045-2322
Publisher URL: http://dx.doi.org/10.1038/s41598-018-28971-0
Publisher DOI: 10.1038/s41598-018-28971-0
Appears in collections:JGU-Publikationen

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