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Authors: Florin, Luise
Lang, Thorsten
Title: Tetraspanin assemblies in virus infection
Online publication date: 19-Dec-2018
Year of first publication: 2018
Language: english
Abstract: Tetraspanins are a family of four-span transmembrane proteins, known as plasma membrane ‘master organizers’. They form tetraspanin-enriched microdomains (TEMs or TERMs) through lateral association with one another and other membrane proteins. If multiple microdomains associate with each other, larger platforms can form. For infection, viruses interact with multiple cell surface components including receptors, activating proteases, and signaling molecules. It appears that tetraspanins such as CD151, CD82, CD81, CD63, CD9, Tspan9, and Tspan7 coordinate these associations by concentrating the interacting partners into tetraspanin platforms. In addition to mediating viral attachment and entry, these platforms may also be involved in intracellular trafficking of internalized viruses and assist in defining virus assembly and exit sites. In conclusion, tetraspanins play a role in viral infection at different stages of the virus replication cycle. The present review highlights recently published data on this topic, with a focus on events at the plasma membrane. In light of these findings, we propose a model for how tetraspanin interactions may organize cofactors for viral infection into distinct molecular platforms.
DDC: 610 Medizin
610 Medical sciences
Institution: Johannes Gutenberg-Universität Mainz
Department: FB 04 Medizin
Place: Mainz
URN: urn:nbn:de:hebis:77-publ-587071
Version: Published version
Publication type: Zeitschriftenaufsatz
License: CC BY
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Journal: Frontiers in immunology
Pages or article number: Art. 1140
Publisher: Frontiers Media
Publisher place: Lausanne
Issue date: 2018
ISSN: 1664-3224
Publisher URL:
Publisher DOI: 10.3389/fimmu.2018.01140
Appears in collections:JGU-Publikationen

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