Please use this identifier to cite or link to this item:
http://doi.org/10.25358/openscience-21
Authors: | Bayer, Franziska Ascher, Stefanie Potarollo, Giulia Reinhardt, Christoph |
Title: | Antibiotic treatment protocols and germ-free mouse models in vascular research |
Online publication date: | 24-Jan-2020 |
Year of first publication: | 2019 |
Language: | english |
Abstract: | The gut microbiota influence host vascular physiology locally in the intestine, but also evoke remote effects that impact distant organ functions. Amongst others, the microbiota affect intestinal vascular remodeling, lymphatic development, cardiac output and vascular function, myelopoiesis, prothrombotic platelet function, and immunovigilance of the host. Experimentally, host-microbiota interactions are investigated by working with animals devoid of symbiotic bacteria, i.e., by the decimation of gut commensals by antibiotic administration, or by taking advantage of germ-free mouse isolator technology. Remarkably, some of the vascular effects that were unraveled following antibiotic treatment were not observed in the germ-free animal models and vice versa. In this review, we will dissect the manifold influences that antibiotics have on the cardiovascular system and their effects on thromboinflammation. |
DDC: | 610 Medizin 610 Medical sciences |
Institution: | Johannes Gutenberg-Universität Mainz |
Department: | FB 04 Medizin Externe Einrichtungen |
Place: | Mainz |
ROR: | https://ror.org/023b0x485 |
DOI: | http://doi.org/10.25358/openscience-21 |
URN: | urn:nbn:de:hebis:77-publ-595205 |
Version: | Published version |
Publication type: | Zeitschriftenaufsatz |
License: | CC BY |
Information on rights of use: | https://creativecommons.org/licenses/by/4.0/ |
Journal: | Frontiers in immunology 10 |
Pages or article number: | Art. 2174 |
Publisher: | Frontiers Media |
Publisher place: | Lausanne |
Issue date: | 2019 |
ISSN: | 1664-3224 |
Publisher URL: | http://dx.doi.org/10.3389/fimmu.2019.02174 |
Publisher DOI: | 10.3389/fimmu.2019.02174 |
Appears in collections: | JGU-Publikationen |