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Authors: Bayer, Franziska
Ascher, Stefanie
Potarollo, Giulia
Reinhardt, Christoph
Title: Antibiotic treatment protocols and germ-free mouse models in vascular research
Online publication date: 24-Jan-2020
Year of first publication: 2019
Language: english
Abstract: The gut microbiota influence host vascular physiology locally in the intestine, but also evoke remote effects that impact distant organ functions. Amongst others, the microbiota affect intestinal vascular remodeling, lymphatic development, cardiac output and vascular function, myelopoiesis, prothrombotic platelet function, and immunovigilance of the host. Experimentally, host-microbiota interactions are investigated by working with animals devoid of symbiotic bacteria, i.e., by the decimation of gut commensals by antibiotic administration, or by taking advantage of germ-free mouse isolator technology. Remarkably, some of the vascular effects that were unraveled following antibiotic treatment were not observed in the germ-free animal models and vice versa. In this review, we will dissect the manifold influences that antibiotics have on the cardiovascular system and their effects on thromboinflammation.
DDC: 610 Medizin
610 Medical sciences
Institution: Johannes Gutenberg-Universität Mainz
Department: FB 04 Medizin
Externe Einrichtungen
Place: Mainz
URN: urn:nbn:de:hebis:77-publ-595205
Version: Published version
Publication type: Zeitschriftenaufsatz
License: CC BY
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Journal: Frontiers in immunology
Pages or article number: Art. 2174
Publisher: Frontiers Media
Publisher place: Lausanne
Issue date: 2019
ISSN: 1664-3224
Publisher URL:
Publisher DOI: 10.3389/fimmu.2019.02174
Appears in collections:JGU-Publikationen

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