Autoren:	Bayer, Franziska Ascher, Stefanie Potarollo, Giulia Reinhardt, Christoph
Titel:	Antibiotic treatment protocols and germ-free mouse models in vascular research
Online-Publikationsdatum:	24-Jan-2020
Erscheinungsdatum:	2019
Sprache des Dokuments:	Englisch
Zusammenfassung/Abstract:	The gut microbiota influence host vascular physiology locally in the intestine, but also evoke remote effects that impact distant organ functions. Amongst others, the microbiota affect intestinal vascular remodeling, lymphatic development, cardiac output and vascular function, myelopoiesis, prothrombotic platelet function, and immunovigilance of the host. Experimentally, host-microbiota interactions are investigated by working with animals devoid of symbiotic bacteria, i.e., by the decimation of gut commensals by antibiotic administration, or by taking advantage of germ-free mouse isolator technology. Remarkably, some of the vascular effects that were unraveled following antibiotic treatment were not observed in the germ-free animal models and vice versa. In this review, we will dissect the manifold influences that antibiotics have on the cardiovascular system and their effects on thromboinflammation.
DDC-Sachgruppe:	610 Medizin 610 Medical sciences
Veröffentlichende Institution:	Johannes Gutenberg-Universität Mainz
Organisationseinheit:	FB 04 Medizin Externe Einrichtungen
Veröffentlichungsort:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-21
URN:	urn:nbn:de:hebis:77-publ-595205
Version:	Published version
Publikationstyp:	Zeitschriftenaufsatz
Nutzungsrechte:	CC BY
Informationen zu den Nutzungsrechten:	https://creativecommons.org/licenses/by/4.0/
Zeitschrift:	Frontiers in immunology 10
Seitenzahl oder Artikelnummer:	Art. 2174
Verlag:	Frontiers Media
Verlagsort:	Lausanne
Erscheinungsdatum:	2019
ISSN:	1664-3224
URL der Originalveröffentlichung:	http://dx.doi.org/10.3389/fimmu.2019.02174
DOI der Originalveröffentlichung:	10.3389/fimmu.2019.02174
Enthalten in den Sammlungen:	JGU-Publikationen