Please use this identifier to cite or link to this item:
http://doi.org/10.25358/openscience-168
Authors: | Boeder, Niklas F. Weissner, Melissa Blachutzik, Florian Ullrich, Helen Anadol, Remzi Tröbs, Monique Münzel, Thomas Hamm, Christian W. Dijkstra, Jouke Achenbach, Stephan Nef, Holger M. Gori, Tommaso |
Title: | Incidental finding of strut malapposition is a predictor of late and very late thrombosis in coronary bioresorbable scaffolds |
Online publication date: | 8-Jul-2019 |
Year of first publication: | 2019 |
Language: | english |
Abstract: | Malapposition is a common finding in stent and scaffold thrombosis (ScT). Evidence from studies with prospective follow-up, however, is scarce. We hypothesized that incidental observations of strut malapposition might be predictive of late ScT during subsequent follow-up. One hundred ninety-seven patients were enrolled in a multicentre registry with prospective follow-up. Optical coherence tomography (OCT), performed in an elective setting, was available in all at 353 (0–376) days after bioresorbable scaffold (BRS) implantation. Forty-four patients showed evidence of malapposition that was deemed not worthy of intervention. Malapposition was not associated with any clinical or procedural parameter except for a higher implantation pressure (p = 0.0008). OCT revealed that malapposition was associated with larger vessel size, less eccentricity (all p < 0.01), and a tendency for more uncovered struts (p = 0.06). Late or very late ScT was recorded in seven of these patients 293 (38–579) days after OCT. OCT-diagnosed malapposition was a predictor of late and very late scaffold thrombosis (p < 0.001) that was independent of the timing of diagnosis. We provide evidence that an incidental finding of malapposition—regardless of the timing of diagnosis of the malapposition—during an elective exam is a predictor of late and very late ScT. Our data provide a rationale to consider prolonged dual antiplatelet therapy if strut malapposition is observed. |
DDC: | 610 Medizin 610 Medical sciences |
Institution: | Johannes Gutenberg-Universität Mainz |
Department: | FB 04 Medizin |
Place: | Mainz |
ROR: | https://ror.org/023b0x485 |
DOI: | http://doi.org/10.25358/openscience-168 |
URN: | urn:nbn:de:hebis:77-publ-591366 |
Version: | Published version |
Publication type: | Zeitschriftenaufsatz |
License: | CC BY |
Information on rights of use: | https://creativecommons.org/licenses/by/4.0/ |
Journal: | Journal of Clinical Medicine 8 5 |
Pages or article number: | Art. 580 |
Publisher: | MDPI |
Publisher place: | Basel |
Issue date: | 2019 |
ISSN: | 2077-0383 |
Publisher URL: | http://dx.doi.org/10.3390/jcm8050580 |
Publisher DOI: | 10.3390/jcm8050580 |
Appears in collections: | JGU-Publikationen |