Authors:	Ritter, Katharina Somnuke, Pawit Hu, Lingjiao Griemert, Eva-Verena Schäfer, Michael K.E.
Title:	Current state of neuroprotective therapy using antibiotics in human traumatic brain injury and animal models
Online publication date:	15-Mar-2024
Year of first publication:	2024
Language:	english
Abstract:	TBI is a leading cause of death and disability in young people and older adults worldwide. There is no gold standard treatment for TBI besides surgical interventions and symptomatic relief. Post-injury infections, such as lower respiratory tract and surgical site infections or meningitis are frequent complications following TBI. Whether the use of preventive and/or symptomatic antibiotic therapy improves patient mortality and outcome is an ongoing matter of debate. In contrast, results from animal models of TBI suggest translational perspectives and support the hypothesis that antibiotics, independent of their anti-microbial activity, alleviate secondary injury and improve neurological outcomes. These beneficial effects were largely attributed to the inhibition of neuroinflammation and neuronal cell death. In this review, we briefly outline current treatment options, including antibiotic therapy, for patients with TBI. We then summarize the therapeutic effects of the most commonly tested antibiotics in TBI animal models, highlight studies identifying molecular targets of antibiotics, and discuss similarities and differences in their mechanistic modes of action.
DDC:	610 Medizin 610 Medical sciences
Institution:	Johannes Gutenberg-Universität Mainz
Department:	FB 04 Medizin
Place:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-10221
Version:	Published version
Publication type:	Zeitschriftenaufsatz
Document type specification:	Review
License:	CC BY
Information on rights of use:	https://creativecommons.org/licenses/by/4.0/
Journal:	BMC neuroscience 25
Pages or article number:	10
Publisher:	BioMed Central
Publisher place:	London
Issue date:	2024
ISSN:	1471-2202
Publisher DOI:	10.1186/s12868-024-00851-6
Appears in collections:	DFG-491381577-G