Authors:	Minarrieta, Lucía Godoy, Gloria J. Velazquez, Lis N. Ghorbani, Peyman Sparwasser, Tim Berod, Luciana
Title:	Regulation of DC metabolism by nitric oxide in murine GM-CSF cultures
Online publication date:	8-Mar-2024
Year of first publication:	2022
Language:	english
Abstract:	The CD11c+MHCII+ compartment within GM-CSF cultures consists of a MHCIIlowCD11bhigh population (GM-Macs) and a MHCIIhighCD11bint population (GM-DCs), with different metabolic profiles. GM-Macs upregulate iNOS and produce nitric oxide (NO) upon TLR activation inhibiting mitochondrial respiration (OXPHOS) while promoting glycolytic metabolism in GM-DCs, which naturally do not express iNOS.
DDC:	610 Medizin 610 Medical sciences
Institution:	Johannes Gutenberg-Universität Mainz
Department:	FB 04 Medizin
Place:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-10170
Version:	Published version
Publication type:	Zeitschriftenaufsatz
Document type specification:	Other
License:	CC BY-NC-ND
Information on rights of use:	https://creativecommons.org/licenses/by-nc-nd/4.0/
Journal:	European journal of immunology 53 2
Pages or article number:	2149691
Publisher:	Wiley
Publisher place:	Weinheim
Issue date:	2022
ISSN:	1521-4141
Publisher DOI:	10.1002/eji.202149691
Appears in collections:	DFG-491381577-H