Regulation of DC metabolism by nitric oxide in murine GM-CSF cultures

Minarrieta, Lucía; Godoy, Gloria J.; Velazquez, Lis N.; Ghorbani, Peyman; Sparwasser, Tim; Berod, Luciana

doi:http://doi.org/10.25358/openscience-10170

Regulation of DC metabolism by nitric oxide in murine GM-CSF cultures

dc.contributor.author	Minarrieta, Lucía
dc.contributor.author	Godoy, Gloria J.
dc.contributor.author	Velazquez, Lis N.
dc.contributor.author	Ghorbani, Peyman
dc.contributor.author	Sparwasser, Tim
dc.contributor.author	Berod, Luciana
dc.date.accessioned	2024-03-08T14:02:23Z
dc.date.available	2024-03-08T14:02:23Z
dc.date.issued	2022
dc.description.abstract	The CD11c+MHCII+ compartment within GM-CSF cultures consists of a MHCIIlowCD11bhigh population (GM-Macs) and a MHCIIhighCD11bint population (GM-DCs), with different metabolic profiles. GM-Macs upregulate iNOS and produce nitric oxide (NO) upon TLR activation inhibiting mitochondrial respiration (OXPHOS) while promoting glycolytic metabolism in GM-DCs, which naturally do not express iNOS.	en_GB
dc.identifier.doi	http://doi.org/10.25358/openscience-10170
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/10188
dc.language.iso	eng	de
dc.rights	CC-BY-NC-ND-4.0	*
dc.rights.uri	https://creativecommons.org/licenses/by-nc-nd/4.0/	*
dc.subject.ddc	610 Medizin	de_DE
dc.subject.ddc	610 Medical sciences	en_GB
dc.title	Regulation of DC metabolism by nitric oxide in murine GM-CSF cultures	en_GB
dc.type	Zeitschriftenaufsatz	de
jgu.journal.issue	2	de
jgu.journal.title	European journal of immunology	de
jgu.journal.volume	53	de
jgu.organisation.department	FB 04 Medizin	de
jgu.organisation.name	Johannes Gutenberg-Universität Mainz
jgu.organisation.number	2700
jgu.organisation.place	Mainz
jgu.organisation.ror	https://ror.org/023b0x485
jgu.pages.alternative	2149691	de
jgu.publisher.doi	10.1002/eji.202149691	de
jgu.publisher.issn	1521-4141	de
jgu.publisher.name	Wiley	de
jgu.publisher.place	Weinheim	de
jgu.publisher.year	2022
jgu.rights.accessrights	openAccess
jgu.subject.ddccode	610	de
jgu.subject.dfg	Lebenswissenschaften	de
jgu.type.contenttype	Other	de
jgu.type.dinitype	Article	en_GB
jgu.type.resource	Text	de
jgu.type.version	Published version	de

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