Regulation of DC metabolism by nitric oxide in murine GM-CSF cultures

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dc.contributor.authorMinarrieta, Lucía
dc.contributor.authorGodoy, Gloria J.
dc.contributor.authorVelazquez, Lis N.
dc.contributor.authorGhorbani, Peyman
dc.contributor.authorSparwasser, Tim
dc.contributor.authorBerod, Luciana
dc.date.accessioned2024-03-08T14:02:23Z
dc.date.available2024-03-08T14:02:23Z
dc.date.issued2022
dc.description.abstractThe CD11c+MHCII+ compartment within GM-CSF cultures consists of a MHCIIlowCD11bhigh population (GM-Macs) and a MHCIIhighCD11bint population (GM-DCs), with different metabolic profiles. GM-Macs upregulate iNOS and produce nitric oxide (NO) upon TLR activation inhibiting mitochondrial respiration (OXPHOS) while promoting glycolytic metabolism in GM-DCs, which naturally do not express iNOS.en_GB
dc.identifier.doihttp://doi.org/10.25358/openscience-10170
dc.identifier.urihttps://openscience.ub.uni-mainz.de/handle/20.500.12030/10188
dc.language.isoeng
dc.rightsCC-BY-NC-ND-4.0
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc610 Medizinde_DE
dc.subject.ddc610 Medical sciencesen_GB
dc.titleRegulation of DC metabolism by nitric oxide in murine GM-CSF culturesen_GB
dc.typeZeitschriftenaufsatzde_DE
jgu.apc.transformationcontractWiley (DEAL)
jgu.dfg.year2022
jgu.journal.issue2
jgu.journal.titleEuropean journal of immunology
jgu.journal.volume53
jgu.organisation.departmentFB 04 Medizinde_DE
jgu.organisation.nameJohannes Gutenberg-Universität Mainzde_DE
jgu.organisation.number2700
jgu.organisation.placeMainz
jgu.organisation.rorhttps://ror.org/023b0x485
jgu.pages.alternative2149691
jgu.publisher.doi10.1002/eji.202149691
jgu.publisher.issn1521-4141
jgu.publisher.nameWiley
jgu.publisher.placeWeinheim
jgu.publisher.year2022
jgu.rights.accessrightsopenAccessen_GB
jgu.subject.ddccode610
jgu.subject.dfgLebenswissenschaftende_DE
jgu.type.contenttypeOtheren_GB
jgu.type.dinitypeArticleen_GB
jgu.type.resourceTexten_GB
jgu.type.versionPublished versionen_GB

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