Authors:	Wolf, Elias V. Müller, Lukas Schoepf, U. Joseph Fink, Nicola Griffith III., Joseph P. Zsarnocza, Emese Baruah, Dhiraj Suranyi, Pal Kabakus, Ismael Halfmann, Moritz C. Emrich, Tilman Varga-Szemes, Akos O'Doherty, Jim
Title:	Photon-counting detector CT-based virtual monoenergetic reconstructions: repeatability and reproducibility of radiomics features of an organic phantom and human myocardium
Online publication date:	4-Mar-2024
Year of first publication:	2023
Language:	english
Abstract:	Background Photon‑counting detector computed tomography (PCD‑CT) may influence imaging characteristics for various clinical conditions due to higher signal and contrast‑to‑noise ratio in virtual monoenergetic images (VMI). Radiomics analysis relies on quantification of image characteristics. We evaluated the impact of different VMI reconstructions on radiomic features in in vitro and in vivo PCD‑CT datasets. Methods An organic phantom consisting of twelve samples (four oranges, four onions, and four apples) was scanned five times. Twenty‑three patients who had undergone coronary computed tomography angiography on a first generation PCD‑CT system with the same image acquisitions were analyzed. VMIs were reconstructed at 6 keV levels (40, 55, 70, 90, 120, and 190 keV). The phantoms and the patients’ left ventricular myocardium (LVM) were segmented for all reconstructions. Ninety‑three original radiomic features were extracted. Repeatability and reproducibility were evaluated through intraclass correlations coefficient (ICC) and post hoc paired samples ANOVA t test. Results There was excellent repeatability for radiomic features in phantom scans (all ICC = 1.00). Among all VMIs, 36/93 radiomic features (38.7%) in apples, 28/93 (30.1%) in oranges, and 33/93 (35.5%) in onions were not significantly different. For LVM, the percentage of stable features was high between VMIs ≥ 90 keV (90 versus 120 keV, 77.4%; 90 versus 190 keV, 83.9%; 120 versus 190 keV, 89.3%), while comparison to lower VMI levels led to fewer reproducible features (40 versus 55 keV, 8.6%). Conclusions VMI levels influence the stability of radiomic features in an organic phantom and patients’ LVM; stability decreases considerably below 90 keV. Relevance statement Spectral reconstructions significantly influence radiomic features in vitro and in vivo, necessitating standardization and careful attention to these reconstruction parameters before clinical implementation.
DDC:	610 Medizin 610 Medical sciences
Institution:	Johannes Gutenberg-Universität Mainz
Department:	FB 04 Medizin
Place:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-10151
Version:	Published version
Publication type:	Zeitschriftenaufsatz
Document type specification:	Scientific article
License:	CC BY
Information on rights of use:	https://creativecommons.org/licenses/by/4.0/
Journal:	European Radiology Experimental 7.2023
Pages or article number:	59
Publisher:	Springer International Publishing
Publisher place:	[Cham]
Issue date:	2023
ISSN:	2509-9280
Publisher DOI:	10.1186/s41747-023-00371-8
Appears in collections:	DFG-491381577-G