Authors:	Kapphan, Laura Malina Nguyen, Vu Thu Thuy Heinrich, Isabel Tüscher, Oliver Passauer, Pamela Schwiertz, Andreas Endres, Kristina
Title:	Comparison of frailty and chronological age as determinants of the murine gut microbiota in an Alzheimer’s disease mouse model
Online publication date:	19-Feb-2024
Year of first publication:	2023
Language:	english
Abstract:	The ageing of an organism is associated with certain features of functional decline that can be assessed at the cellular level (e.g., reduced telomere length, loss of proteostasis, etc.), but also at the organismic level. Frailty is an independent syndrome that involves increased multidimensional age-related deficits, heightens vulnerability to stressors, and involves physical deficits in mainly the locomotor/muscular capacity, but also in physical appearance and cognition. For sporadic Alzheimer’s disease, age per se is one of the most relevant risk factors, but frailty has also been associated with this disease. Therefore, we aimed to answer the two following questions within a cross-sectional study: (1) do Alzheimer’s model mice show increased frailty, and (2) what changes of the microbiota occur concerning chronological age or frailty? Indeed, aged 5xFAD mice showed increased frailty compared to wild type littermates. In addition, 5xFAD mice had significantly lower quantities of Bacteroides spp. when only considering frailty, and lower levels of Bacteroidetes in terms of both frailty and chronological age compared to their wild type littermates. Thus, the quality of ageing—as assessed by frailty measures—should be taken into account to unravel potential changes in the gut microbial community in Alzheimer’s disease.
DDC:	610 Medizin 610 Medical sciences
Institution:	Johannes Gutenberg-Universität Mainz
Department:	FB 04 Medizin
Place:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-10053
Version:	Published version
Publication type:	Zeitschriftenaufsatz
Document type specification:	Scientific article
License:	CC BY
Information on rights of use:	https://creativecommons.org/licenses/by/4.0/
Journal:	Microorganisms 11 12
Pages or article number:	2856
Publisher:	MDPI
Publisher place:	Basel
Issue date:	2023
ISSN:	2076-2607
Publisher DOI:	10.3390/microorganisms11122856
Appears in collections:	DFG-491381577-G