Authors:	Buonfiglio, Francesco Böhm, Elsa Wilma Pfeiffer, Norbert Gericke, Adrian
Title:	Oxidative stress : a suitable therapeutic target for optic nerve diseases?
Online publication date:	19-Feb-2024
Year of first publication:	2023
Language:	english
Abstract:	Optic nerve disorders encompass a wide spectrum of conditions characterized by the loss of retinal ganglion cells (RGCs) and subsequent degeneration of the optic nerve. The etiology of these disorders can vary significantly, but emerging research highlights the crucial role of oxidative stress, an imbalance in the redox status characterized by an excess of reactive oxygen species (ROS), in driving cell death through apoptosis, autophagy, and inflammation. This review provides an overview of ROS-related processes underlying four extensively studied optic nerve diseases: glaucoma, Leber’s hereditary optic neuropathy (LHON), anterior ischemic optic neuropathy (AION), and optic neuritis (ON). Furthermore, we present preclinical findings on antioxidants, with the objective of evaluating the potential therapeutic benefits of targeting oxidative stress in the treatment of optic neuropathies.
DDC:	610 Medizin 610 Medical sciences
Institution:	Johannes Gutenberg-Universität Mainz
Department:	FB 04 Medizin
Place:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-10051
Version:	Published version
Publication type:	Zeitschriftenaufsatz
Document type specification:	Scientific article
License:	CC BY
Information on rights of use:	https://creativecommons.org/licenses/by/4.0/
Journal:	Antioxidants 12 7
Pages or article number:	1465
Publisher:	MDPI
Publisher place:	Basel
Issue date:	2023
ISSN:	2076-3921
Publisher DOI:	10.3390/antiox12071465
Appears in collections:	DFG-491381577-G