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http://doi.org/10.25358/openscience-10037| Authors: | Man, Andy W. C. Zhou, Yawen Xia, Ning Li, Huige |
| Title: | Perivascular adipose tissue oxidative stress in obesity |
| Online publication date: | 19-Feb-2024 |
| Year of first publication: | 2023 |
| Language: | english |
| Abstract: | Perivascular adipose tissue (PVAT) adheres to most systemic blood vessels in the body. Healthy PVAT exerts anticontractile effects on blood vessels and further protects against cardiovascular and metabolic diseases. Healthy PVAT regulates vascular homeostasis via secreting an array of adipokine, hormones, and growth factors. Normally, homeostatic reactive oxygen species (ROS) in PVAT act as secondary messengers in various signalling pathways and contribute to vascular tone regulation. Excessive ROS are eliminated by the antioxidant defence system in PVAT. Oxidative stress occurs when the production of ROS exceeds the endogenous antioxidant defence, leading to a redox imbalance. Oxidative stress is a pivotal pathophysiological process in cardiovascular and metabolic complications. In obesity, PVAT becomes dysfunctional and exerts detrimental effects on the blood vessels. Therefore, redox balance in PVAT emerges as a potential pathophysiological mechanism underlying obesity-induced cardiovascular diseases. In this review, we summarise new findings describing different ROS, the major sources of ROS and antioxidant defence in PVAT, as well as potential pharmacological intervention of PVAT oxidative stress in obesity. |
| DDC: | 610 Medizin 610 Medical sciences |
| Institution: | Johannes Gutenberg-Universität Mainz |
| Department: | FB 04 Medizin |
| Place: | Mainz |
| ROR: | https://ror.org/023b0x485 |
| DOI: | http://doi.org/10.25358/openscience-10037 |
| Version: | Published version |
| Publication type: | Zeitschriftenaufsatz |
| Document type specification: | Scientific article |
| License: | CC BY |
| Information on rights of use: | https://creativecommons.org/licenses/by/4.0/ |
| Journal: | Antioxidants 12 8 |
| Pages or article number: | 1595 |
| Publisher: | MDPI |
| Publisher place: | Basel |
| Issue date: | 2023 |
| ISSN: | 2076-3921 |
| Publisher DOI: | 10.3390/antiox12081595 |
| Appears in collections: | DFG-491381577-G |
Files in This Item:
| File | Description | Size | Format | ||
|---|---|---|---|---|---|
 | perivascular_adipose_tissue_o-20240205155633372.pdf | 2.11 MB | Adobe PDF | View/Open |