Authors:	Mirzac, Daniela Kreis, Svenja L. Luhmann, Heiko J. Gonzalez-Escamilla, Gabriel Groppa, Sergiu
Title:	Translating pathological brain activity primers in Parkinson’s disease research
Online publication date:	16-Feb-2024
Year of first publication:	2023
Language:	english
Abstract:	Translational experimental approaches that help us better trace Parkinson’s disease (PD) pathophysiological mechanisms leading to new therapeutic targets are urgently needed. In this article, we review recent experimental and clinical studies addressing abnormal neuronal activity and pathological network oscillations, as well as their underlying mechanisms and modulation. Our aim is to enhance our knowledge about the progression of Parkinson's disease pathology and the timing of its symptom’s manifestation. Here, we present mechanistic insights relevant for the generation of aberrant oscillatory activity within the cortico-basal ganglia circuits. We summarize recent achievements extrapolated from available PD animal models, discuss their advantages and limitations, debate on their differential applicability, and suggest approaches for transferring knowledge on disease pathology into future research and clinical applications.
DDC:	610 Medizin 610 Medical sciences
Institution:	Johannes Gutenberg-Universität Mainz
Department:	FB 04 Medizin
Place:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-10023
Version:	Published version
Publication type:	Zeitschriftenaufsatz
Document type specification:	Scientific article
License:	CC BY
Information on rights of use:	https://creativecommons.org/licenses/by/4.0/
Journal:	Research 6
Pages or article number:	0183
Publisher:	China Association for Science and Technology
Publisher place:	Beijing
Issue date:	2023
ISSN:	2639-5274
Publisher DOI:	10.34133/research.0183
Appears in collections:	DFG-491381577-G