Forensic application and evaluation of a commercially available pregabalin immunoassay test in serum on an Olympus AU480

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dc.contributor.authorHess, Cornelius
dc.contributor.authorZeidler, Sandra
dc.contributor.authorRöhrich, Jörg
dc.date.accessioned2022-04-27T10:10:56Z
dc.date.available2022-04-27T10:10:56Z
dc.date.issued2021
dc.description.abstractMisuse of pregabalin and its forensic relevance is steadily increasing. The aim of this study was to evaluate the usability of the commercially available ARKTM Pregabalin II Assay (ARK Diagnostics) for serum analysis of forensic samples. Overall, 156 samples were tested by both the immunoassay and a validated liquid chromatographic–tandem mass spectrometric (LC-MS/MS) method. Sensitivity was 100%, and specificity was 98.7% (n = 79 positive cases confirmed by LC-MS/MS in a range of 380–37,000 ng/mL). A good correlation (R2 = 0.73) could also be shown between quantitative immunoassay and LC-MS/MS results. In conclusion, the assay shows excellent reliability for screening of forensic serum samples.en_GB
dc.identifier.doihttp://doi.org/10.25358/openscience-6912
dc.identifier.urihttps://openscience.ub.uni-mainz.de/handle/20.500.12030/6923
dc.language.isoengde
dc.rightsCC-BY-4.0*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subject.ddc610 Medizinde_DE
dc.subject.ddc610 Medical sciencesen_GB
dc.titleForensic application and evaluation of a commercially available pregabalin immunoassay test in serum on an Olympus AU480en_GB
dc.typeZeitschriftenaufsatzde
jgu.journal.issue6de
jgu.journal.titleDrug testing and analysisde
jgu.journal.volume13de
jgu.organisation.departmentFB 04 Medizinde
jgu.organisation.nameJohannes Gutenberg-Universität Mainz
jgu.organisation.number2700
jgu.organisation.placeMainz
jgu.organisation.rorhttps://ror.org/023b0x485
jgu.pages.end1218de
jgu.pages.start1216de
jgu.publisher.doi10.1002/dta.2994de
jgu.publisher.issn1942-7611de
jgu.publisher.nameWileyde
jgu.publisher.placeHoboken, NJde
jgu.publisher.year2021
jgu.rights.accessrightsopenAccess
jgu.subject.ddccode610de
jgu.type.dinitypeArticleen_GB
jgu.type.resourceTextde
jgu.type.versionPublished versionde

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