Selektive RNA-Modifizierung durch OREOs

Simple item page
dc.contributor.authorSchartel, Lukas
dc.contributor.authorLemke, Edward A.
dc.date.accessioned2026-07-21T14:03:44Z
dc.date.issued2025
dc.description.abstractRNA modifications are key regulators of cellular processes, yet selectively introducing these modifications into target RNAs remains challenging. We developed “designer organelles” to perform highly selective, guide-RNA-driven pseudouridylation of mRNA in living cells. Circular guide RNAs further enhance modification efficiency and specificity. These orthogonal RNA editing organelles (OREOs) thus represent a versatile new approach to precise RNA modification, with promising applications from basic research to therapeutic interventions.en_GB
dc.identifier.doihttps://doi.org/10.25358/openscience-15467
dc.identifier.urihttps://openscience.ub.uni-mainz.de/handle/20.500.12030/15488
dc.language.isoger
dc.rightsCC-BY-4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subject.ddc570 Biowissenschaftende_DE
dc.subject.ddc570 Life sciencesen_GB
dc.titleSelektive RNA-Modifizierung durch OREOsde_DE
dc.typeZeitschriftenaufsatzde_DE
jgu.apc.netprice2453,72
jgu.apc.price2625,48
jgu.apc.taxrate7
jgu.apc.transformationcontractSpringer (DEAL)
jgu.dfg.year2025
jgu.identifier.uuidbba717b6-4d55-456f-be88-0e4fd20b5c29
jgu.journal.titleBiospektrum
jgu.journal.volume31
jgu.nationalcurrency.eur2453,72
jgu.organisation.departmentFB 10 Biologiede_DE
jgu.organisation.nameJohannes Gutenberg-Universität Mainzde_DE
jgu.organisation.number7970
jgu.organisation.placeMainz
jgu.organisation.rorhttps://ror.org/023b0x485
jgu.pages.end450
jgu.pages.start449
jgu.publisher.doi10.1007/s12268-025-2500-2
jgu.publisher.eissn1868-6249
jgu.publisher.issn0947-0867
jgu.publisher.nameSpringer Nature
jgu.publisher.placeHeidelberg
jgu.publisher.year2025
jgu.rights.accessrightsopenAccessen_GB
jgu.subject.ddccode570
jgu.subject.dfgLebenswissenschaftende_DE
jgu.type.dinitypeArticleen_GB
jgu.type.resourceTexten_GB
jgu.type.versionPublished versionen_GB

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
selektive_rnamodifizierung_du-20260721160344151159.pdf
Size:
411.58 KB
Format:
Adobe Portable Document Format
Download

License bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
5.14 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

DFG-491381577-H