Selektive RNA-Modifizierung durch OREOs
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Abstract
RNA modifications are key regulators of cellular processes, yet selectively introducing these modifications into target RNAs remains challenging. We developed “designer organelles” to perform highly selective, guide-RNA-driven pseudouridylation of mRNA in living cells. Circular guide RNAs further enhance modification efficiency and specificity. These orthogonal RNA editing organelles (OREOs) thus represent a versatile new approach to precise RNA modification, with promising applications from basic research to therapeutic interventions.