Intrabronchial application of extracellular histones shows no proinflammatory effects in swine in a translational pilot study

dc.contributor.authorRuemmler, Robert
dc.contributor.authorZiebart, Alexander
dc.contributor.authorBritten, Elisabeth
dc.contributor.authorGosling, Moritz
dc.contributor.authorRissel, Rene
dc.contributor.authorHartmann, Erik K.
dc.date.accessioned2022-07-05T09:38:43Z
dc.date.available2022-07-05T09:38:43Z
dc.date.issued2021
dc.description.abstractObjective Extracellular histones have been identified as one molecular factor that can cause and sustain alveolar damage and were linked to high mortality rates in critically ill patients. In this pilot study, we wanted to validate the proinflammatory in vivo effects of local histone application in a prospective translational porcine model. This was combined with the evaluation of an experimental acute lung injury model using intrabronchial lipopolysaccharides, which has been published previously. Results The targeted application of histones was successful in all animals. Animals showed decreased oxygenation after instillation, but no differences could be detected between the sham and histone treatments. The histologic analyses and inflammatory responses indicated that there were no differences in tissue damage between the groups.en_GB
dc.identifier.doihttp://doi.org/10.25358/openscience-7311
dc.identifier.urihttps://openscience.ub.uni-mainz.de/handle/20.500.12030/7325
dc.language.isoengde
dc.rightsCC-BY-4.0*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subject.ddc610 Medizinde_DE
dc.subject.ddc610 Medical sciencesen_GB
dc.titleIntrabronchial application of extracellular histones shows no proinflammatory effects in swine in a translational pilot studyen_GB
dc.typeZeitschriftenaufsatzde
jgu.journal.titleBMC Research Notesde
jgu.journal.volume14de
jgu.organisation.departmentFB 04 Medizinde
jgu.organisation.nameJohannes Gutenberg-Universität Mainz
jgu.organisation.number2700
jgu.organisation.placeMainz
jgu.organisation.rorhttps://ror.org/023b0x485
jgu.pages.alternative285de
jgu.publisher.doi10.1186/s13104-021-05704-7de
jgu.publisher.issn1756-0500de
jgu.publisher.nameBioMed Centralde
jgu.publisher.placeLondonde
jgu.publisher.year2021
jgu.rights.accessrightsopenAccess
jgu.subject.ddccode610de
jgu.type.dinitypeArticleen_GB
jgu.type.resourceTextde
jgu.type.versionPublished versionde

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