Variation of platelet function in clinical phenotypes of acute venous thromboembolism : results from the GMP-VTE project

dc.contributor.authorPanova-Noeva, Marina
dc.contributor.authorWagner, Bianca
dc.contributor.authorNagler, Markus
dc.contributor.authorKoeck, Thomas
dc.contributor.authorten Cate, Vincent
dc.contributor.authorEggebrecht, Lisa
dc.contributor.authorProchaska, Jürgen H.
dc.contributor.authorMeyer, Imke
dc.contributor.authorGerdes, Christoph
dc.contributor.authorSpronk, Henri M.
dc.contributor.authorLackner, Karl J.
dc.contributor.authorten Cate, Hugo
dc.contributor.authorLeineweber, Kirsten
dc.contributor.authorHeitmeier, Stefan
dc.contributor.authorKonstantinides, Stavros
dc.contributor.authorWild, Philipp S.
dc.date.accessioned2022-09-06T08:51:27Z
dc.date.available2022-09-06T08:51:27Z
dc.date.issued2022
dc.description.abstractBackground The role of platelets in the pathogenesis of venous thromboembolism (VTE) is receiving increasing attention; however, limited information is available on platelet function in the acute phase of the disease. Objective To characterize platelet function according to VTE phenotypes. Patients/Methods In total, 154 subjects (isolated pulmonary embolism [iPE], n = 28; isolated deep vein thrombosis [iDVT], n = 35; DVT+PE, n = 91) were included. In this study platelet function analyzer (PFA)-200, light transmission aggregometry (LTA), thrombin generation (TG) in presence (PRP) and absence (PFP) of platelets and platelet flow cytometry were investigated. LASSO regression was used to select clinical and platelet biomarkers that distinguish between VTE phenotypes. Results PFA-200 results did not differ between VTE phenotypes. LTA from DVT+PE subjects showed lowest maximum aggregation after epinephrine and adenosine diphosphate compared to iPE and iDVT. Lower % of PAC-1-positive platelets after in-vitro trigger were present in DVT+PE and iPE compared to iDVT. TG in PRP had lower peak height and velocity in DVT+PE and iPE against iDVT. The results of LASSO regression for the distinction between DVT+PE vs iDVT identified 18 variables (AUC =0.93) of which 72% were platelet biomarkers. For distinction between iPE and iDVT, 10 variables were selected (AUC = 0.96) of which 50% were platelet-related. Obesity was the only variable weakly discriminating between DVT+PE vs iPE (AUC = 0.66). Conclusion This explorative study suggests an important distinction between PE-related phenotypes and iDVT when considering clinical and platelet function data. Lower platelet-dependent TG along with reduced platelet reactivity suggest higher platelet degranulation in PE-dependent phenotypes compared to iDVT.en_GB
dc.identifier.doihttp://doi.org/10.25358/openscience-7679
dc.identifier.urihttps://openscience.ub.uni-mainz.de/handle/20.500.12030/7694
dc.language.isoengde
dc.rightsCC-BY-NC-ND-4.0*
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subject.ddc610 Medizinde_DE
dc.subject.ddc610 Medical sciencesen_GB
dc.titleVariation of platelet function in clinical phenotypes of acute venous thromboembolism : results from the GMP-VTE projecten_GB
dc.typeZeitschriftenaufsatzde
jgu.journal.issue3de
jgu.journal.titleJournal of thrombosis and haemostasisde
jgu.journal.volume20de
jgu.organisation.departmentFB 04 Medizinde
jgu.organisation.nameJohannes Gutenberg-Universität Mainz
jgu.organisation.number2700
jgu.organisation.placeMainz
jgu.organisation.rorhttps://ror.org/023b0x485
jgu.pages.end715de
jgu.pages.start705de
jgu.publisher.doi10.1111/jth.15595de
jgu.publisher.issn1538-7836de
jgu.publisher.nameWiley-Blackwellde
jgu.publisher.placeOxford
jgu.publisher.year2022
jgu.rights.accessrightsopenAccess
jgu.subject.ddccode610de
jgu.type.dinitypeArticleen_GB
jgu.type.resourceTextde
jgu.type.versionPublished versionde

Files

Original bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
variation_of_platelet_functio-20220902150739508.pdf
Size:
961.05 KB
Format:
Adobe Portable Document Format
Description:

License bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
license.txt
Size:
3.57 KB
Format:
Item-specific license agreed upon to submission
Description: