A short route to midazolam via Michael addition to a nitroolefin
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Abstract
A new approach to midazolam through Michael addition of 2-aminobenzophenone with a nitroolefin as a key step is reported. We devised a telescoped four-step synthesis using only one single protecting group, resulting in an excellent atom economy.
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Organic process research & development, 29, 11, American Chemical Society, Washington, DC, 2025, https://doi.org/10.1021/acs.oprd.5c00320