Comparative characteristics of older people with type 1 diabetes treated with continuous subcutaneous insulin infusion or insulin injection therapy : data from the German/Austrian DPV registry
| dc.contributor.author | Grammes, Jennifer | |
| dc.contributor.author | Küstner, E. | |
| dc.contributor.author | Dapp, A. | |
| dc.contributor.author | Hummel, M. | |
| dc.contributor.author | Kämmer, J.-C. | |
| dc.contributor.author | Kubiak, Thomas | |
| dc.contributor.author | Schütz-Fuhrmann, I. | |
| dc.contributor.author | Zimny, S. | |
| dc.contributor.author | Bollow, E. | |
| dc.contributor.author | Holl, R. W. | |
| dc.date.accessioned | 2021-08-03T10:09:15Z | |
| dc.date.available | 2021-08-03T10:09:15Z | |
| dc.date.issued | 2020 | |
| dc.description.abstract | AIM To compare clinical characteristics and outcomes in adults with type 1 diabetes aged ≥ 60 years using continuous subcutaneous insulin infusion (CSII) vs. insulin injection therapy. Further, to determine the percentage of older adults with type 1 diabetes using CSII. RESEARCH DESIGN AND METHODS Retrospective study using data of the Diabetes Prospective Follow-up Registry (DPV). Including percentage CSII use from 2008 to 2018, and the characteristics of 9547 individuals extracted from the DPV in March 2019 (N = 1404 CSII; N = 8143 insulin injection therapy). Wilcoxon rank sum tests were used for continuous variables and chi-square tests for categorical variables to compare clinical characteristics of people using CSII vs. insulin injection therapy. Adjusted analyses used generalized linear models to compare diabetes-related outcomes. RESULTS CSII usage has increased in older adults (from 12% in 2008 to 23% in 2018). After adjustment, CSII was associated with lower HbA1c [60.7 mmol/mol (7.7 ± 0.1%) vs. 62.8% (7.9 ± 0.1%)], lower daily insulin dose (0.49 ± 0.02 vs. 0.61 ± 0.01 IU/kg), fewer days in hospital (8.1 ± 0.12 vs. 11.2 ± 0.11 days/person-year), fewer severe hypoglycaemic events (0.16 ± 0.02 vs. 0.21 ± 0.03 events/person-year) and fewer diabetic ketoacidosis (0.06 ± 0.01 vs. 0.08 ± 0.01 events/person-year). Individuals on CSII showed lower rates of microalbuminuria and also have a diagnosis of depression and neuropathy. CONCLUSIONS A growing number of older adults are using insulin pumps. Older age in itself should not be seen as a contraindication for CSII. | en_GB |
| dc.identifier.doi | http://doi.org/10.25358/openscience-6235 | |
| dc.identifier.uri | https://openscience.ub.uni-mainz.de/handle/20.500.12030/6245 | |
| dc.language.iso | eng | de |
| dc.rights | CC-BY-NC-4.0 | * |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | * |
| dc.subject.ddc | 610 Medizin | de_DE |
| dc.subject.ddc | 610 Medical sciences | en_GB |
| dc.title | Comparative characteristics of older people with type 1 diabetes treated with continuous subcutaneous insulin infusion or insulin injection therapy : data from the German/Austrian DPV registry | en_GB |
| dc.type | Zeitschriftenaufsatz | de |
| jgu.journal.issue | 5 | de |
| jgu.journal.title | Diabetic medicine | de |
| jgu.journal.volume | 37 | de |
| jgu.organisation.department | FB 02 Sozialwiss., Medien u. Sport | de |
| jgu.organisation.name | Johannes Gutenberg-Universität Mainz | |
| jgu.organisation.number | 7910 | |
| jgu.organisation.place | Mainz | |
| jgu.organisation.ror | https://ror.org/023b0x485 | |
| jgu.pages.end | 862 | de |
| jgu.pages.start | 856 | de |
| jgu.publisher.doi | 10.1111/dme.14218 | |
| jgu.publisher.issn | 1464-5491 | de |
| jgu.publisher.name | Wiley-Blackwell | de |
| jgu.publisher.place | Oxford u.a. | de |
| jgu.publisher.uri | https://doi.org/10.1111/dme.14218 | de |
| jgu.publisher.year | 2020 | |
| jgu.rights.accessrights | openAccess | |
| jgu.subject.ddccode | 610 | de |
| jgu.type.dinitype | Article | en_GB |
| jgu.type.resource | Text | de |
| jgu.type.version | Published version | de |