Neonatal plasmacytoid dendritic cells at the interface of innate and adaptive immunity
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Abstract
Human cord blood plasmacytoid dendritic cells (PDC) react to stimulation with CPG A and CPG B with an increase in cell surface activation and maturation markers and cytokine production, similar to adult PDC. Intracellular phosphorylation in neonatal PDC did not benefit from CPG stimulation, in contrast to adult PDC. Cord blood PDC primed with CPG A, CPG B and CD40L do not promote division of autologous T cells contrary to adult PDC. Priming of neonatal PDC with CPG A or CPG B does not induce a clear bias in T helper cell response towards Th1 or Th2 while adult PDC trend towards a Th2 response.