Autoren:	Gerber, Tiemo S. Ridder, Dirk A. Goeppert, Benjamin Brobeil, Alexander Stenzel, Philipp Zimmer, Stefanie Jäkel, Jörg Metzig, Marie Oliver Schwab, Roxana Martin, Steve Z. Kiss, András Bergmann, Frank Schirmacher, Peter Galle, Peter R. Lang, Hauke Roth, Wilfried Straub, Beate K.
Titel:	N-cadherin: a diagnostic marker to help discriminate primary liver carcinomas from extrahepatic carcinomas
Online-Publikationsdatum:	19-Jan-2024
Erscheinungsdatum:	2024
Sprache des Dokuments:	Englisch
Zusammenfassung/Abstract:	Distinguishing primary liver cancer (PLC), namely hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA), from liver metastases is of crucial clinical importance. Histopathology remains the gold standard, but differential diagnosis may be challenging. While absent in most epithelial, the expression of the adherens junction glycoprotein N-cadherin is commonly restricted to neural and mesenchymal cells, or carcinoma cells that undergo the phenomenon of epithelial-to-mesenchymal transition (EMT). However, we recently established N- and E-cadherin expression as hallmarks of normal hepatocytes and cholangiocytes, which are also preserved in HCC and iCCA. Therefore, we hypothesized that E- and/or N-cadherin may distinguish between carcinoma derived from the liver vs carcinoma of other origins. We comprehensively evaluated E- and N-cadherin in 3359 different tumors in a multicenter study using immunohistochemistry and compared our results with previously published 882 cases of PLC, including 570 HCC and 312 iCCA. Most carcinomas showed strong positivity for E-cadherin. Strong N-cadherin positivity was present in HCC and iCCA. However, except for clear cell renal cell carcinoma (23.6% of cases) and thyroid cancer (29.2%), N-cadherin was only in some instances faintly expressed in adenocarcinomas of the gastrointestinal tract (0%–0.5%), lung (7.1%), pancreas (3.9%), gynecological organs (0%–7.4%), breast (2.2%) as well as in urothelial (9.4%) and squamous cell carcinoma (0%–5.6%). As expected, N-cadherin was detected in neuroendocrine tumors (25%–75%), malignant melanoma (46.2%) and malignant mesothelioma (41%). In conclusion, N-cadherin is a useful marker for the distinction of PLC vs liver metastases of extrahepatic carcinomas (P < .01).
DDC-Sachgruppe:	610 Medizin 610 Medical sciences
Veröffentlichende Institution:	Johannes Gutenberg-Universität Mainz
Organisationseinheit:	FB 04 Medizin
Veröffentlichungsort:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-9945
Version:	Published version
Publikationstyp:	Zeitschriftenaufsatz
Nutzungsrechte:	CC BY
Informationen zu den Nutzungsrechten:	https://creativecommons.org/licenses/by/4.0/
Zeitschrift:	International journal of cancer Version of Record (VoR)
Verlag:	Wiley-Liss,
Verlagsort:	Bognor Regis
Erscheinungsdatum:	2024
DOI der Originalveröffentlichung:	10.1002/ijc.34836
Enthalten in den Sammlungen:	DFG-491381577-H