N-cadherin: a diagnostic marker to help discriminate primary liver carcinomas from extrahepatic carcinomas

dc.contributor.authorGerber, Tiemo S.
dc.contributor.authorRidder, Dirk A.
dc.contributor.authorGoeppert, Benjamin
dc.contributor.authorBrobeil, Alexander
dc.contributor.authorStenzel, Philipp
dc.contributor.authorZimmer, Stefanie
dc.contributor.authorJäkel, Jörg
dc.contributor.authorMetzig, Marie Oliver
dc.contributor.authorSchwab, Roxana
dc.contributor.authorMartin, Steve Z.
dc.contributor.authorKiss, András
dc.contributor.authorBergmann, Frank
dc.contributor.authorSchirmacher, Peter
dc.contributor.authorGalle, Peter R.
dc.contributor.authorLang, Hauke
dc.contributor.authorRoth, Wilfried
dc.contributor.authorStraub, Beate K.
dc.date.accessioned2024-01-19T08:22:43Z
dc.date.available2024-01-19T08:22:43Z
dc.date.issued2024
dc.description.abstractDistinguishing primary liver cancer (PLC), namely hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA), from liver metastases is of crucial clinical importance. Histopathology remains the gold standard, but differential diagnosis may be challenging. While absent in most epithelial, the expression of the adherens junction glycoprotein N-cadherin is commonly restricted to neural and mesenchymal cells, or carcinoma cells that undergo the phenomenon of epithelial-to-mesenchymal transition (EMT). However, we recently established N- and E-cadherin expression as hallmarks of normal hepatocytes and cholangiocytes, which are also preserved in HCC and iCCA. Therefore, we hypothesized that E- and/or N-cadherin may distinguish between carcinoma derived from the liver vs carcinoma of other origins. We comprehensively evaluated E- and N-cadherin in 3359 different tumors in a multicenter study using immunohistochemistry and compared our results with previously published 882 cases of PLC, including 570 HCC and 312 iCCA. Most carcinomas showed strong positivity for E-cadherin. Strong N-cadherin positivity was present in HCC and iCCA. However, except for clear cell renal cell carcinoma (23.6% of cases) and thyroid cancer (29.2%), N-cadherin was only in some instances faintly expressed in adenocarcinomas of the gastrointestinal tract (0%–0.5%), lung (7.1%), pancreas (3.9%), gynecological organs (0%–7.4%), breast (2.2%) as well as in urothelial (9.4%) and squamous cell carcinoma (0%–5.6%). As expected, N-cadherin was detected in neuroendocrine tumors (25%–75%), malignant melanoma (46.2%) and malignant mesothelioma (41%). In conclusion, N-cadherin is a useful marker for the distinction of PLC vs liver metastases of extrahepatic carcinomas (P < .01).en_GB
dc.identifier.doihttp://doi.org/10.25358/openscience-9945
dc.identifier.urihttps://openscience.ub.uni-mainz.de/handle/20.500.12030/9963
dc.language.isoengde
dc.rightsCC-BY-4.0*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subject.ddc610 Medizinde_DE
dc.subject.ddc610 Medical sciencesen_GB
dc.titleN-cadherin: a diagnostic marker to help discriminate primary liver carcinomas from extrahepatic carcinomasen_GB
dc.typeZeitschriftenaufsatzde
jgu.journal.titleInternational journal of cancerde
jgu.journal.volumeVersion of Record (VoR)de
jgu.organisation.departmentFB 04 Medizinde
jgu.organisation.nameJohannes Gutenberg-Universität Mainz
jgu.organisation.number2700
jgu.organisation.placeMainz
jgu.organisation.rorhttps://ror.org/023b0x485
jgu.publisher.doi10.1002/ijc.34836de
jgu.publisher.nameWiley-Liss,de
jgu.publisher.placeBognor Regisde
jgu.publisher.year2024
jgu.rights.accessrightsopenAccess
jgu.subject.ddccode610de
jgu.subject.dfgLebenswissenschaftende
jgu.type.dinitypeArticleen_GB
jgu.type.resourceTextde
jgu.type.versionPublished versionde

Files

Original bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
ncadherin__a_diagnostic_marke-20240119091111297.pdf
Size:
134.28 MB
Format:
Adobe Portable Document Format
Description:

License bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
license.txt
Size:
3.57 KB
Format:
Item-specific license agreed upon to submission
Description:

Collections