Authors:	Hahad, Omar Schmidt, Frank P. Hübner, Jonas Foos, Patrick Al-Kindi, Sadeer Schmitt, Volker H. Hobohm, Lukas Keller, Karsten Große-Dresselhaus, Christina Schmeißer, Julian Koppe-Schmeißer, Franziska Vosseler, Markus Gilan, Donya Schulz, Andreas Chalabi, Julian Wild, Philipp S. Daiber, Andreas Herzog, Johannes Münzel, Thomas
Title:	Acute exposure to simulated nocturnal traffic noise and cardiovascular complications and sleep disturbance : results from a pooled analysis of human field studies
Online publication date:	8-Jan-2024
Year of first publication:	2023
Language:	english
Abstract:	Objectives A series of human field studies demonstrated that acute exposure to simulated nocturnal traffic noise is associated with cardiovascular complications and sleep disturbance, including endothelial dysfunction, increased blood pressure, and impaired sleep quality. A pooled analysis of these results remains to be established and is of tremendous interest to consolidate scientific knowledge. Methods We analyzed data from four randomized crossover studies (published between 2013 to 2021 and conducted at the University Medical Center Mainz, Germany). A total of 275 subjects (40.4% women, mean age 43.03 years) were each exposed to one control scenario (regular background noise) and at least to one traffic noise scenario (60 aircraft or train noise events) in their homes during nighttime. After each night, the subjects visited the study center for comprehensive cardiovascular function assessment, including the measurement of endothelial function and hemodynamic and biochemical parameters, as well as sleep-related variables. Results The pooled analysis revealed a significantly impaired endothelial function when comparing the two different noise sequences (0–60 vs. 60–0 simulated noise events, mean difference in flow-mediated dilation −2.00%, 95% CI −2.32; −1.68, p < 0.0001). In concordance, mean arterial pressure was significantly increased after traffic noise exposure (mean difference 2.50 mmHg, 95% CI 0.54; 4.45, p = 0.013). Self-reported sleep quality, the restfulness of sleep, and feeling in the morning were significantly impaired after traffic noise exposure (all p < 0.0001). Discussion Acute exposure to simulated nocturnal traffic noise is associated with endothelial dysfunction, increased mean arterial pressure, and sleep disturbance.
DDC:	610 Medizin 610 Medical sciences
Institution:	Johannes Gutenberg-Universität Mainz
Department:	FB 04 Medizin
Place:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-9865
Version:	Published version
Publication type:	Zeitschriftenaufsatz
License:	CC BY
Information on rights of use:	https://creativecommons.org/licenses/by/4.0/
Journal:	Clinical research in cardiology 112
Pages or article number:	1690 1698
Publisher:	Springer
Publisher place:	Berlin
Issue date:	2023
ISSN:	1861-0692
Publisher DOI:	10.1007/s00392-023-02297-y
Appears in collections:	DFG-491381577-H