Gutenberg Open Science: Temporal patterns of childhood cancer survival 1991 to 2016 : a nationwide register-study based on data from the German Childhood Cancer Registry

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-9530

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DC Field	Value	Language
dc.contributor.author	Wellbrock, Maike	-
dc.contributor.author	Spix, Claudia	-
dc.contributor.author	Ronckers, Cécile M.	-
dc.contributor.author	Grabow, Desiree	-
dc.contributor.author	Filbert, Anna-Liesa	-
dc.contributor.author	Borkhardt, Arndt	-
dc.contributor.author	Wollschläger, Daniel	-
dc.contributor.author	Erdmann, Friederike	-
dc.date.accessioned	2023-09-12T09:57:39Z	-
dc.date.available	2023-09-12T09:57:39Z	-
dc.date.issued	2023	-
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/9548	-
dc.description.abstract	Childhood cancer is the leading disease-related cause of death among under 15 year olds in Europe. Since primary preventive measures are lacking, improving survival probabilities and long-term well-being remain primary goals. With this report, we provide the first long-term assessment and interpretation of patterns in childhood cancer survival in Germany, covering a period of 30 years. Using data from the German Childhood Cancer Registry, we assessed temporal patterns of cancer survival among children (0-14 years) diagnosed in Germany from 1991 to 2016, by cancer type, age at diagnosis and sex. We calculated overall survival (OS) and average annual percentage changes of the respective 5-year OS estimates. OS improved across all cancer types, age groups as well as for boys and girls over time. Five-year OS for all childhood cancers combined increased from 77.8% in 1991-1995 to 86.5% in 2011-2016, with stronger improvements during the early 1990s. The most pronounced survival improvement was seen for acute myeloid leukaemia, at 2% annually and 5-year OS recently reaching 81.5%. Survival improvements for some diagnoses such as neuroblastoma, renal tumours and bone tumours have flattened out. Tremendous enhancements in diagnostics, treatment and supportive care have affected average survival improvements for most cancer types. Recently, survival improvements have decelerated overall and for some cancer types, it plateaued at an unsatisfactory level. As not all children benefited equally from the survival improvements, personal factors (eg, socioeconomic circumstances, health literacy, access to care) likely affect individual prognosis and warrant further investigation.	en_GB
dc.description.sponsorship	Deutsche Forschungsgemeinschaft (DFG)\|491381577\|Open-Access-Publikationskosten 2022–2024 Universität Mainz - Universitätsmedizin	-
dc.language.iso	eng	de
dc.rights	CC BY	*
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	*
dc.subject.ddc	610 Medizin	de_DE
dc.subject.ddc	610 Medical sciences	en_GB
dc.title	Temporal patterns of childhood cancer survival 1991 to 2016 : a nationwide register-study based on data from the German Childhood Cancer Registry	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-9530	-
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 04 Medizin	de
jgu.organisation.number	2700	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	International journal of cancer	de
jgu.journal.volume	153	de
jgu.journal.issue	4	de
jgu.pages.start	742	de
jgu.pages.end	755	de
jgu.publisher.year	2023	-
jgu.publisher.name	Wiley-Liss	de
jgu.publisher.place	Bognor Regis	de
jgu.publisher.issn	1097-0215	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	610	de
jgu.publisher.doi	10.1002/ijc.34556	de
jgu.organisation.ror	https://ror.org/023b0x485	-
Appears in collections:	DFG-491381577-H

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