Please use this identifier to cite or link to this item:
http://doi.org/10.25358/openscience-9475
Authors: | Kao, Yu-San Mamareli, Panagiota Dhillon-LaBrooy, Ayesha Stüve, Philipp Godoy, Gloria Janet Velasquez, Lis Noelia Raker, Verena Katharina Weidenthaler-Barth, Beate Boukhallouk, Fatima Rampoldi, Francesca Berod, Luciana Sparwasser, Tim |
Title: | Targeting ACC1 in T cells ameliorates psoriatic skin inflammation |
Online publication date: | 29-Aug-2023 |
Year of first publication: | 2023 |
Language: | english |
Abstract: | Psoriasis is a chronic inflammatory skin disease driven by the IL-23/IL-17 axis. It results from excessive activation of effector T cells, including T helper (Th) and cytotoxic T (Tc) cells, and is associated with dysfunctional regulatory T cells (Tregs). Acetyl-CoA carboxylase 1 (ACC1), a rate-limiting enzyme of fatty acid synthesis (FAS), directs cell fate decisions between Th17 and Tregs and thus could be a promising therapeutic target for psoriasis treatment. Here, we demonstrate that targeting ACC1 in T cells by genetic ablation ameliorates skin inflammation in an experimental model of psoriasis by limiting Th17, Tc17, Th1, and Tc1 cells in skin lesions and increasing the frequency of effector Tregs in skin-draining lymph nodes (LNs). |
DDC: | 610 Medizin 610 Medical sciences |
Institution: | Johannes Gutenberg-Universität Mainz |
Department: | FB 04 Medizin |
Place: | Mainz |
ROR: | https://ror.org/023b0x485 |
DOI: | http://doi.org/10.25358/openscience-9475 |
Version: | Published version |
Publication type: | Zeitschriftenaufsatz |
License: | CC BY |
Information on rights of use: | https://creativecommons.org/licenses/by/4.0/ |
Journal: | Journal of molecular medicine Version of Record (VoR) |
Publisher: | Springer |
Publisher place: | Berlin u.a. |
Issue date: | 2023 |
ISSN: | 1432-1440 |
Publisher DOI: | 10.1007/s00109-023-02349-w |
Appears in collections: | DFG-491381577-H |
Files in This Item:
File | Description | Size | Format | ||
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![]() | targeting_acc1_in_t_cells_ame-20230821184700662.pdf | 4.25 MB | Adobe PDF | View/Open |