Authors:	Buhl, Roland Dreher, Michael Mattiucci-Guehlke, Muriel Emerson-Stadler, Rachel Eckhardt, Sebastian Taube, Christian Vogelmeier, Claus F.
Title:	EVELUT®: a real-world, observational study assessing dyspnoea and symptom burden in COPD patients switched from LABA/ICS to LAMA/LABA or LAMA/LABA/ICS
Online publication date:	24-Aug-2023
Year of first publication:	2023
Language:	english
Abstract:	Introduction The Global Initiative for Chronic Obstructive Lung Disease (GOLD 2023) no longer recommends a long-acting β2-agonist (LABA) plus inhaled corticosteroid (ICS) combination for the treatment of chronic obstructive pulmonary disease (COPD). In patients treated with LABA/ICS, who continue to experience symptoms without frequent or severe exacerbations, GOLD now recommends switching to long-acting muscarinic antagonist (LAMA)/LABA instead of escalating to triple therapy (TT; LAMA/LABA/ICS), which previously was also a recommended option. EVELUT®, a real-life, observational study, compared these two treatment strategies in terms of symptom relief and health status improvement. Methods Patients with symptomatic COPD at low exacerbation risk (GOLD B) were switched, at their physicians’ discretion, from LABA/ICS to either fixed-dose LAMA/LABA (tiotropium/olodaterol, Respimat® [Tio/Olo]) or fixed or free TT. Primary endpoints were change in modified Medical Research Council (mMRC) and COPD Assessment Test™ (CAT™) scores after 12 weeks. Results The safety set contained 463 patients (Tio/Olo, n = 329; TT, n = 134). In a propensity score-matched set (Tio/Olo, n = 121; TT, n = 121), improvement in mMRC score was similar in patients on Tio/Olo (–0.23; 95% confidence interval [CI] –0.11, –0.36) and TT (–0.25; 95% CI –0.13, –0.38). Improvement in total CAT score was slightly larger in patients on Tio/Olo (–3.45; 95% CI –2.45, –4.45) versus TT (–2.51; 95% CI –1.62, –3.40). In both groups, Physician’s Global Evaluation scores increased, with 69–89% of patients satisfied with their treatment overall. Marginally more patients on Tio/Olo responded to treatment versus TT (Δ mMRC score ≥ 1; 25% vs. 22%; Δ CAT score ≥ 2, 68% vs. 56%). Conclusion In patients with symptomatic COPD at low exacerbation risk, treatment can be switched from LABA/ICS to LAMA/LABA without compromising clinical benefit, compared with escalating to LAMA/LABA/ICS. Switching from LABA/ICS to LAMA/LABA can provide symptom relief and improve health status without exposure to the risks associated with ICS.
DDC:	610 Medizin 610 Medical sciences
Institution:	Johannes Gutenberg-Universität Mainz
Department:	FB 04 Medizin
Place:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-9468
Version:	Published version
Publication type:	Zeitschriftenaufsatz
License:	CC BY-NC
Information on rights of use:	https://creativecommons.org/licenses/by-nc/4.0/
Journal:	Advances in therapy 40
Pages or article number:	3263 3278
Publisher:	Springer Healthcare Communications
Publisher place:	Tarporley
Issue date:	2023
ISSN:	1865-8652
Publisher DOI:	10.1007/s12325-023-02524-y
Appears in collections:	DFG-491381577-H