Please use this identifier to cite or link to this item:
http://doi.org/10.25358/openscience-9454
Authors: | Büttner, Matthias Krogh, Dieter Siggelkow, Heide Singer, Susanne |
Title: | Impairments in quality of life and predictors of symptom burden in patients with hypoparathyroidism: results from a population-based survey |
Online publication date: | 28-Aug-2023 |
Year of first publication: | 2023 |
Language: | english |
Abstract: | Purpose To investigate the quality of life (QoL) in patients with hypoparathyroidism (hypoPT) compared to the general population and to identify sociodemographic and clinical factors that are associated with symptom burden. Methods Patients with a diagnosis of hypoPT participated in an online survey. Information regarding the survey was distributed by treating physicians or a self-help organization. Quality of life was assessed using the EORTC QLQ-C30 and symptom burden using the Hypoparathyroid Patient Questionnaire (HPQ28). Multivariate linear regression analysis was used to compare QoL of hypoPT patients with the general population (adjusted for age, sex, education)and to identify factors associated with symptom burden. Results Altogether, 264 hypoPT patients provided information on QoL and symptom burden. HypoPT was associated with worse cognitive (β = −15.9; p < 0.01) and emotional functioning (β = −12.3; p = 0.04) compared to the general population. The highest symptom burden in hypoPT patients was observed for the domains loss of vitality (mean: 61.4; SD: 21.9), pain and cramps (mean: 43.7; SD: 26.5), and numbness and tingling sensations (mean: 38.9; SD: 30.0). Female gender was associated with a higher symptom burden across all nine domains of the HPQ28, while longer disease duration was associated with a lower symptom burden in neurovegetative symptoms, loss of vitality, depression and anxiety, and depressive symptoms. Conclusion HypoPT patients have impaired QoL compared to the general population. Being female is strongly associated with high symptom burden. |
DDC: | 610 Medizin 610 Medical sciences |
Institution: | Johannes Gutenberg-Universität Mainz |
Department: | FB 04 Medizin |
Place: | Mainz |
ROR: | https://ror.org/023b0x485 |
DOI: | http://doi.org/10.25358/openscience-9454 |
Version: | Published version |
Publication type: | Zeitschriftenaufsatz |
License: | CC BY |
Information on rights of use: | https://creativecommons.org/licenses/by/4.0/ |
Journal: | Endocrine Version of Record (VoR) |
Publisher: | Springer |
Issue date: | 2023 |
ISSN: | 1559-0100 |
Publisher DOI: | 10.1007/s12020-023-03443-2 |
Appears in collections: | DFG-491381577-H |
Files in This Item:
File | Description | Size | Format | ||
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![]() | impairments_in_quality_of_lif-20230818171738292.pdf | 454.15 kB | Adobe PDF | View/Open |