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Authors: Luhmann, Heiko J.
Title: Dynamics of neocortical networks : connectivity beyond the canonical microcircuit
Online publication date: 22-Aug-2023
Year of first publication: 2023
Language: english
Abstract: The neocortical network consists of two types of excitatory neurons and a variety of GABAergic inhibitory interneurons, which are organized in distinct microcircuits providing feedforward, feedback, lateral inhibition, and disinhibition. This network is activated by layer- and cell-type specific inputs from first and higher order thalamic nuclei, other subcortical regions, and by cortico-cortical projections. Parallel and serial information processing occurs simultaneously in different intracortical subnetworks and is influenced by neuromodulatory inputs arising from the basal forebrain (cholinergic), raphe nuclei (serotonergic), locus coeruleus (noradrenergic), and ventral tegmentum (dopaminergic). Neocortical neurons differ in their intrinsic firing pattern, in their local and global synaptic connectivity, and in the dynamics of their synaptic interactions. During repetitive stimulation, synaptic connections between distinct neuronal cell types show short-term facilitation or depression, thereby activating or inactivating intracortical microcircuits. Specific networks are capable to generate local and global activity patterns (e.g., synchronized oscillations), which contribute to higher cognitive function and behavior. This review article aims to give a brief overview on our current understanding of the structure and function of the neocortical network.
DDC: 610 Medizin
610 Medical sciences
Institution: Johannes Gutenberg-Universität Mainz
Department: FB 04 Medizin
Place: Mainz
Version: Published version
Publication type: Zeitschriftenaufsatz
License: CC BY
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Journal: Pflügers Archiv : European journal of physiology
Pages or article number: 1027
Publisher: Springer
Publisher place: Berlin u.a.
Issue date: 2023
ISSN: 1432-2013
Publisher DOI: 10.1007/s00424-023-02830-y
Appears in collections:DFG-491381577-H

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