Please use this identifier to cite or link to this item:
http://doi.org/10.25358/openscience-9336
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Fahrer, Jörg | - |
dc.contributor.author | Christmann, Markus | - |
dc.date.accessioned | 2023-08-08T06:50:07Z | - |
dc.date.available | 2023-08-08T06:50:07Z | - |
dc.date.issued | 2023 | - |
dc.identifier.uri | https://openscience.ub.uni-mainz.de/handle/20.500.12030/9354 | - |
dc.description.abstract | Nitrosamines occur widespread in food, drinking water, cosmetics, as well as tobacco smoke and can arise endogenously. More recently, nitrosamines have been detected as impurities in various drugs. This is of particular concern as nitrosamines are alkylating agents that are genotoxic and carcinogenic. We first summarize the current knowledge on the different sources and chemical nature of alkylating agents with a focus on relevant nitrosamines. Subsequently, we present the major DNA alkylation adducts induced by nitrosamines upon their metabolic activation by CYP450 monooxygenases. We then describe the DNA repair pathways engaged by the various DNA alkylation adducts, which include base excision repair, direct damage reversal by MGMT and ALKBH, as well as nucleotide excision repair. Their roles in the protection against the genotoxic and carcinogenic effects of nitrosamines are highlighted. Finally, we address DNA translesion synthesis as a DNA damage tolerance mechanism relevant to DNA alkylation adducts. | en_GB |
dc.description.sponsorship | Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 491381577 | de |
dc.language.iso | eng | de |
dc.rights | CC BY | * |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | * |
dc.subject.ddc | 610 Medizin | de_DE |
dc.subject.ddc | 610 Medical sciences | en_GB |
dc.title | DNA alkylation damage by nitrosamines and relevant DNA repair pathways | en_GB |
dc.type | Zeitschriftenaufsatz | de |
dc.identifier.doi | http://doi.org/10.25358/openscience-9336 | - |
jgu.type.contenttype | Scientific article | de |
jgu.type.dinitype | article | en_GB |
jgu.type.version | Published version | de |
jgu.type.resource | Text | de |
jgu.organisation.department | FB 04 Medizin | de |
jgu.organisation.number | 2700 | - |
jgu.organisation.name | Johannes Gutenberg-Universität Mainz | - |
jgu.rights.accessrights | openAccess | - |
jgu.journal.title | International journal of molecular sciences | de |
jgu.journal.volume | 24 | de |
jgu.journal.issue | 5 | de |
jgu.pages.alternative | 4684 | de |
jgu.publisher.year | 2023 | - |
jgu.publisher.name | MDPI | de |
jgu.publisher.place | Basel | de |
jgu.publisher.issn | 1422-0067 | de |
jgu.organisation.place | Mainz | - |
jgu.subject.ddccode | 610 | de |
jgu.publisher.doi | 10.3390/ijms24054684 | de |
jgu.organisation.ror | https://ror.org/023b0x485 | - |
jgu.subject.dfg | Naturwissenschaften | de |
Appears in collections: | DFG-491381577-G |
Files in This Item:
File | Description | Size | Format | ||
---|---|---|---|---|---|
dna_alkylation_damage_by_nitr-20230802113742518.pdf | 4.66 MB | Adobe PDF | View/Open |