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Authors: Winkelmeier, Laurens
Filosa, Carla
Hartig, Renée
Scheller, Max
Sack, Markus
Reinwald, Jonathan R.
Becker, Robert
Wolf, David
Gerchen, Martin Fungisai
Sartorius, Alexander
Meyer-Lindenberg, Andreas
Fahr-Weber, Wolfgang
Clemm von Hohenberg, Christian
Russo, Eleonora
Kelsch, Wolfgang
Title: Striatal hub of dynamic and stabilized prediction coding in forebrain networks for olfactory reinforcement learning
Online publication date: 10-Feb-2023
Year of first publication: 2022
Language: english
Abstract: Identifying the circuits responsible for cognition and understanding their embedded computations is a challenge for neuroscience. We establish here a hierarchical cross-scale approach, from behavioral modeling and fMRI in task-performing mice to cellular recordings, in order to disentangle local network contributions to olfactory reinforcement learning. At mesoscale, fMRI identifies a functional olfactory-striatal network interacting dynamically with higher-order cortices. While primary olfactory cortices respectively contribute only some value components, the downstream olfactory tubercle of the ventral striatum expresses comprehensively reward prediction, its dynamic updating, and prediction error components. In the tubercle, recordings reveal two underlying neuronal populations with non-redundant reward prediction coding schemes. One population collectively produces stabilized predictions as distributed activity across neurons; in the other, neurons encode value individually and dynamically integrate the recent history of uncertain outcomes. These findings validate a cross-scale approach to mechanistic investigations of higher cognitive functions in rodents.
DDC: 610 Medizin
610 Medical sciences
Institution: Johannes Gutenberg-Universität Mainz
Department: FB 04 Medizin
Place: Mainz
Version: Published version
Publication type: Zeitschriftenaufsatz
License: CC BY
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Journal: Nature Communications
Pages or article number: 3305
Publisher: Nature Publishing Group
Publisher place: London
Issue date: 2022
ISSN: 2041-1723
Publisher DOI: 10.1038/s41467-022-30978-1
Appears in collections:DFG-491381577-G

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