Please use this identifier to cite or link to this item:
http://doi.org/10.25358/openscience-8637
Authors: | Srivastava, Raj Kamal Lutz, Beat Ruiz de Azua, Inigo |
Title: | The microbiome and gut endocannabinoid system in the regulation of stress responses and metabolism |
Online publication date: | 25-Jan-2023 |
Year of first publication: | 2022 |
Language: | english |
Abstract: | The endocannabinoid system, with its receptors and ligands, is present in the gut epithelium and enteroendocrine cells, and is able to modulate brain functions, both indirectly through circulating gut-derived factors and directly through the vagus nerve, finally acting on the brain’s mechanisms regarding metabolism and behavior. The gut endocannabinoid system also regulates gut motility, permeability, and inflammatory responses. Furthermore, microbiota composition has been shown to influence the activity of the endocannabinoid system. This review examines the interaction between microbiota, intestinal endocannabinoid system, metabolism, and stress responses. We hypothesize that the crosstalk between microbiota and intestinal endocannabinoid system has a prominent role in stress-induced changes in the gut-brain axis affecting metabolic and mental health. Inter-individual differences are commonly observed in stress responses, but mechanisms underlying resilience and vulnerability to stress are far from understood. Both gut microbiota and the endocannabinoid system have been implicated in stress resilience. We also discuss interventions targeting the microbiota and the endocannabinoid system to mitigate metabolic and stress-related disorders. |
DDC: | 610 Medizin 610 Medical sciences |
Institution: | Johannes Gutenberg-Universität Mainz |
Department: | FB 04 Medizin |
Place: | Mainz |
ROR: | https://ror.org/023b0x485 |
DOI: | http://doi.org/10.25358/openscience-8637 |
Version: | Published version |
Publication type: | Zeitschriftenaufsatz |
Document type specification: | Scientific article |
License: | CC BY |
Information on rights of use: | https://creativecommons.org/licenses/by/4.0/ |
Journal: | Frontiers in cellular neuroscience 16 |
Pages or article number: | 867267 |
Publisher: | Frontiers Research Foundation |
Publisher place: | Lausanne |
Issue date: | 2022 |
ISSN: | 1662-5102 |
Publisher DOI: | 10.3389/fncel.2022.867267 |
Appears in collections: | DFG-491381577-G |
Files in This Item:
File | Description | Size | Format | ||
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![]() | the_microbiome_and_gut_endoca-20230124113438879.pdf | 1.82 MB | Adobe PDF | View/Open |