Gutenberg Open Science: Review article: post-TIPSS hepatic encephalopathy—current knowledge and future perspectives

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-8624

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DC Field	Value	Language
dc.contributor.author	Gairing, Simon Johannes	-
dc.contributor.author	Müller, Lukas	-
dc.contributor.author	Kloeckner, Roman	-
dc.contributor.author	Galle, Peter R.	-
dc.contributor.author	Labenz, Christian	-
dc.date.accessioned	2023-01-23T08:44:12Z	-
dc.date.available	2023-01-23T08:44:12Z	-
dc.date.issued	2022	-
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/8640	-
dc.description.abstract	Background In light of the global rise in the burden of chronic liver diseases and liver cirrhosis, the number of patients suffering from decompensation events is expected to increase. Transjugular intrahepatic portosystemic shunts (TIPSS) provide effective long-term symptom control and may prolong transplant-free survival in portal hypertension-driven recurrent ascites and variceal bleeding. New-onset or recurrent hepatic encephalopathy (HE) after TIPSS insertion (post-TIPSS HE) represents the most severe post-interventional complication. Aims To provide insight into the epidemiology and risk factors for post-TIPSS HE and scrutinize the current state of the art in treatment and drug therapy options. Methods We conducted a literature search on post-TIPSS HE in patients with liver cirrhosis. Results Post-TIPSS HE occurs in up to 54.5% of cases and particularly early recurrent HE is associated with a dismal prognosis. In recent years, several risk factors for the development of post-TIPSS HE have been identified. These include not only parameters reflecting liver function (model for end-stage liver disease score/Child-Pugh score) as well as cognitive dysfunction caused by minimal HE but also extrahepatic factors such as sarcopenia and common medications such as proton pump inhibitors. In addition, new data on the benefit of rifaximin and of smaller stent grafts emerged and may improve the prevention of post-TIPSS HE. Conclusions Careful selection of TIPSS candidates is of utmost importance to reduce the risk of post-TIPSS HE. In this narrative review, we provide a concise overview of the current epidemiology and risk factors of the treatment options for post-TIPSS HE.	en_GB
dc.description.sponsorship	Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 491381577	de
dc.language.iso	eng	de
dc.rights	CC BY-NC	*
dc.rights.uri	https://creativecommons.org/licenses/by-nc/4.0/	*
dc.subject.ddc	610 Medizin	de_DE
dc.subject.ddc	610 Medical sciences	en_GB
dc.title	Review article: post-TIPSS hepatic encephalopathy—current knowledge and future perspectives	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-8624	-
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 04 Medizin	de
jgu.organisation.number	2700	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	Alimentary pharmacology & therapeutics	de
jgu.journal.volume	55	de
jgu.journal.issue	10	de
jgu.pages.start	1265	de
jgu.pages.end	1276	de
jgu.publisher.year	2022	-
jgu.publisher.name	Blackwell Science	de
jgu.publisher.place	Oxford	de
jgu.publisher.issn	1365-2036	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	610	de
jgu.publisher.doi	10.1111/apt.16825	de
jgu.organisation.ror	https://ror.org/023b0x485	-
jgu.subject.dfg	Lebenswissenschaften	de
Appears in collections:	DFG-491381577-H

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