Gutenberg Open Science: Integrative analysis of intrahepatic cholangiocarcinoma subtypes for improved patient stratification : clinical, pathological, and radiological considerations

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-8587

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DC Field	Value	Language
dc.contributor.author	Gerber, Tiemo S.	-
dc.contributor.author	Müller, Lukas	-
dc.contributor.author	Bartsch, Fabian	-
dc.contributor.author	Gröger, Lisa-Katharina	-
dc.contributor.author	Schindeldecker, Mario	-
dc.contributor.author	Ridder, Dirk A.	-
dc.contributor.author	Goeppert, Benjamin	-
dc.contributor.author	Möhler, Markus	-
dc.contributor.author	Dueber, Christoph	-
dc.contributor.author	Lang, Hauke	-
dc.contributor.author	Roth, Wilfried	-
dc.contributor.author	Kloeckner, Roman	-
dc.contributor.author	Straub, Beate K.	-
dc.date.accessioned	2023-01-19T11:22:41Z	-
dc.date.available	2023-01-19T11:22:41Z	-
dc.date.issued	2022	-
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/8603	-
dc.description.abstract	Intrahepatic cholangiocarcinomas (iCCAs) may be subdivided into large and small duct types that differ in etiology, molecular alterations, therapy, and prognosis. Therefore, the optimal iCCA subtyping is crucial for the best possible patient outcome. In our study, we analyzed 148 small and 84 large duct iCCAs regarding their clinical, radiological, histological, and immunohistochemical features. Only 8% of small duct iCCAs, but 27% of large duct iCCAs, presented with initial jaundice. Ductal tumor growth pattern and biliary obstruction were significant radiological findings in 33% and 48% of large duct iCCAs, respectively. Biliary epithelial neoplasia and intraductal papillary neoplasms of the bile duct were detected exclusively in large duct type iCCAs. Other distinctive histological features were mucin formation and periductal-infiltrating growth pattern. Immunohistochemical staining against CK20, CA19-9, EMA, CD56, N-cadherin, and CRP could help distinguish between the subtypes. To summarize, correct subtyping of iCCA requires an interplay of several factors. While the diagnosis of a precursor lesion, evidence of mucin, or a periductal-infiltrating growth pattern indicates the diagnosis of a large duct type, in their absence, several other criteria of diagnosis need to be combined.	en_GB
dc.description.sponsorship	Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 491381577	de
dc.language.iso	eng	de
dc.rights	CC BY	*
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	*
dc.subject.ddc	610 Medizin	de_DE
dc.subject.ddc	610 Medical sciences	en_GB
dc.title	Integrative analysis of intrahepatic cholangiocarcinoma subtypes for improved patient stratification : clinical, pathological, and radiological considerations	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-8587	-
jgu.type.contenttype	Scientific article	de
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 04 Medizin	de
jgu.organisation.number	2700	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	Cancers	de
jgu.journal.volume	14	de
jgu.journal.issue	13	de
jgu.pages.alternative	3156	de
jgu.publisher.year	2022	-
jgu.publisher.name	MDPI	de
jgu.publisher.place	Basel	de
jgu.publisher.issn	2072-6694	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	610	de
jgu.publisher.doi	10.3390/cancers14133156	de
jgu.organisation.ror	https://ror.org/023b0x485	-
jgu.subject.dfg	Lebenswissenschaften	de
Appears in collections:	DFG-491381577-G

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