Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-8583
Authors: Schiegnitz, Eik
Reinikce, Katrin
Sagheb, Keyvan
König, Jochem
Al-Nawas, Bilal
Grötz, Knut A.
Title: Dental implants in patients with head and neck cancer : a systematic review and meta-analysis of the influence of radiotherapy on implant survival
Online publication date: 18-Jan-2023
Year of first publication: 2022
Language: english
Abstract: Purpose The purpose of this meta-analysis was to compare implant survival in irradiated and non-irradiated bone and to investigate potential risk factors for implant therapy in oral cancer patients. Material and methods An extensive search in the electronic databases of the National Library of Medicine was performed. Systematic review and meta-analysis were conducted according to PRISMA statement. The meta-analysis was performed for studies with a mean follow-up of at least three and five years, respectively. Results The systematic review resulted in a mean overall implant survival of 87.8% (34%–100%). The meta-analysis revealed a significantly higher rate of implant failure in irradiated bone compared to non-irradiated bone (p < .00001, OR 1.97, CI [1.63, 2.37]). The studies also showed that implants placed into irradiated grafted bone were more likely to fail than those in irradiated native bone (p < .0001, OR 2.26, CI [1.50, 3.40]). Conclusion Even though overall implant survival was high, radiotherapy proves to be a significant risk factor for implant loss. Augmentation procedures may also increase the risk of an adverse outcome, especially in combination with radiotherapy. Clinical relevance The treatment of patients receiving radiotherapy of any form requires precise individual planning and a close aftercare. Implants should be placed in local bone rather than in bone grafts, if possible.
DDC: 610 Medizin
610 Medical sciences
Institution: Johannes Gutenberg-Universität Mainz
Department: FB 04 Medizin
Place: Mainz
ROR: https://ror.org/023b0x485
DOI: http://doi.org/10.25358/openscience-8583
Version: Published version
Publication type: Zeitschriftenaufsatz
License: CC BY-NC-ND
Information on rights of use: https://creativecommons.org/licenses/by-nc-nd/4.0/
Journal: Clinical oral implants research
33
10
Pages or article number: 967
999
Publisher: Wiley-Blackwell
Publisher place: Oxford
Issue date: 2022
ISSN: 1600-0501
Publisher DOI: 10.1111/clr.13976
Appears in collections:DFG-491381577-H

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