Authors:	Kumari, Jyoti Das, Kinnor Patil, Anant Babaei, Mahsa Cockerell, Clay J. Goldust, Mohamad
Title:	Clinical update on cutaneous and subcutaneous sarcomas
Online publication date:	25-Jan-2023
Year of first publication:	2022
Language:	english
Abstract:	Background: Cutaneous sarcomas are uncommon cancers that can have a wide range of clinical symptoms and lead to considerable cutaneous as well as systemic morbidity.Aim: The objective of this review article is to discuss epidemiology, clinical features, diagnosis, and therapy of different types of cutaneous sarcomas.Material and methods: Literature was screened to retrieve articles from PubMed/Medline and Google Scholar and related websites. Cross- references from the relevant articles were also considered for review. Review articles, clinical studies, system-atic reviews, meta-analyses, and relevant information from selected websites were included.Results and discussion: Cutaneous sarcomas have a negative effect on the quality of life. In their diagnosis, clinical presentation and histological evaluation are crucial. Complete surgical removal is the solution for more or less all cutaneous and subcuta-neous sarcomas. The prognosis for cutaneous sarcomas is generally favorable since they tend to recur locally with distant metastases only on rare occasions. Patients having advanced disease should be treated in the setting of clinical trials if possible; choices include radiation therapy and systemic medicines. The value of innovative im-munotherapy cannot be determined decisively at this time due to a paucity of relevant trials.Conclusion: As cutaneous sarcomas are rarely diagnosed based on clinical findings, histology plays an important role in the diagnosis. They have a relatively favorable prognosis if treated properly. Patients should be treated at specialized centres.
DDC:	610 Medizin 610 Medical sciences
Institution:	Johannes Gutenberg-Universität Mainz
Department:	FB 04 Medizin
Place:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-8548
Version:	Published version
Publication type:	Zeitschriftenaufsatz
License:	CC BY-NC
Information on rights of use:	https://creativecommons.org/licenses/by-nc/4.0/
Journal:	Journal of cosmetic dermatology Version of Record (VoR)
Publisher:	Wiley-Blackwell
Publisher place:	Oxford
Issue date:	2022
ISSN:	1473-2165
Publisher DOI:	10.1111/jocd.15369
Appears in collections:	DFG-491381577-H