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Authors: Müller, Lukas
Mähringer-Kunz, Aline
Auer, Timo Alexander
Fehrenbach, Uli
Gebauer, Bernhard
Haubold, Johannes
Theysohn, Jens M.
Kim, Moon-Sung
Kleesiek, Jens
Diallo, Thierno D.
Eisenblätter, Michel
Bettinger, Dominik
Steinle, Verena
Mayer, Philipp
Zopfs, David
Pinto dos Santos, Daniel
Kloeckner, Roman
Title: Low bone mineral density is a prognostic factor for elderly patients with HCC undergoing TACE : results from a multicenter study
Online publication date: 30-Jan-2023
Year of first publication: 2022
Language: english
Abstract: Objectives Low bone mineral density (BMD) was recently identified as a novel risk factor for patients with hepatocellular carcinoma (HCC). In this multicenter study, we aimed to validate the role of BMD as a prognostic factor for patients with HCC undergoing transarterial chemoembolization (TACE). Methods This retrospective multicenter trial included 908 treatment-naïve patients with HCC who were undergoing TACE as a first-line treatment, at six tertiary care centers, between 2010 and 2020. BMD was assessed by measuring the mean Hounsfield units (HUs) in the midvertebral core of the 11th thoracic vertebra, on contrast-enhanced computer tomography performed before treatment. We assessed the influence of BMD on median overall survival (OS) and performed multivariate analysis including established estimates for survival. Results The median BMD was 145 HU (IQR, 115–175 HU). Patients with a high BMD (≥ 114 HU) had a median OS of 22.2 months, while patients with a low BMD (< 114 HU) had a lower median OS of only 16.2 months (p < .001). Besides albumin, bilirubin, tumor number, and tumor diameter, BMD remained an independent prognostic factor in multivariate analysis. Conclusions BMD is an independent predictive factor for survival in elderly patients with HCC undergoing TACE. The integration of BMD into novel scoring systems could potentially improve survival prediction and clinical decision-making. Key Points • Bone mineral density can be easily assessed in routinely acquired pre-interventional computed tomography scans. • Bone mineral density is an independent predictive factor for survival in elderly patients with HCC undergoing TACE. • Thus, bone mineral density is a novel imaging biomarker for prognosis prediction in elderly patients with HCC undergoing TACE.
DDC: 610 Medizin
610 Medical sciences
Institution: Johannes Gutenberg-Universität Mainz
Department: FB 04 Medizin
Place: Mainz
Version: Published version
Publication type: Zeitschriftenaufsatz
License: CC BY
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Journal: European radiology
Version of Record (VoR)
Publisher: Springer
Publisher place: Berlin u.a.
Issue date: 2022
ISSN: 1432-1084
Publisher DOI: 10.1007/s00330-022-09069-8
Appears in collections:DFG-491381577-H

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