Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-8326
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dc.contributor.authorPaeslack, Nadja-
dc.contributor.authorMimmler, Maximilian-
dc.contributor.authorBecker, Stefanie-
dc.contributor.authorGao, Zhenling-
dc.contributor.authorKhuu, My Phung-
dc.contributor.authorMann, Amrit-
dc.contributor.authorMalinarich, Frano-
dc.contributor.authorRegen, Tommy-
dc.contributor.authorReinhardt, Christoph-
dc.date.accessioned2023-01-04T10:00:21Z-
dc.date.available2023-01-04T10:00:21Z-
dc.date.issued2022-
dc.identifier.urihttps://openscience.ub.uni-mainz.de/handle/20.500.12030/8342-
dc.description.abstractThe essential amino acid tryptophan (Trp) is metabolized by gut commensals, yielding in compounds that affect innate immune cell functions directly, but also acting on the aryl hydrocarbon receptor (AHR), thus regulating the maintenance of group 3 innate lymphoid cells (ILCs), promoting T helper 17 (TH17) cell differentiation, and interleukin-22 production. In addition, microbiota-derived Trp metabolites have direct effects on the vascular endothelium, thus influencing the development of vascular inflammatory phenotypes. Indoxyl sulfate was demonstrated to promote vascular inflammation, whereas indole-3-propionic acid and indole-3-aldehyde had protective roles. Furthermore, there is increasing evidence for a contributory role of microbiota-derived indole-derivatives in blood pressure regulation and hypertension. Interestingly, there are indications for a role of the kynurenine pathway in atherosclerotic lesion development. Here, we provide an overview on the emerging role of gut commensals in the modulation of Trp metabolism and its influence in cardiovascular disease development.en_GB
dc.description.sponsorshipGefördert durch die Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 491381577de
dc.language.isoengde
dc.rightsCC BY*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subject.ddc610 Medizinde_DE
dc.subject.ddc610 Medical sciencesen_GB
dc.titleMicrobiota-derived tryptophan metabolites in vascular inflammation and cardiovascular diseaseen_GB
dc.typeZeitschriftenaufsatzde
dc.identifier.doihttp://doi.org/10.25358/openscience-8326-
jgu.type.dinitypearticleen_GB
jgu.type.versionPublished versionde
jgu.type.resourceTextde
jgu.organisation.departmentFB 04 Medizinde
jgu.organisation.number2700-
jgu.organisation.nameJohannes Gutenberg-Universität Mainz-
jgu.rights.accessrightsopenAccess-
jgu.journal.titleAmino acidsde
jgu.journal.volume54de
jgu.pages.start1339de
jgu.pages.end1356de
jgu.publisher.year2022-
jgu.publisher.nameSpringerde
jgu.publisher.placeWien u.a.de
jgu.publisher.issn1438-2199de
jgu.organisation.placeMainz-
jgu.subject.ddccode610de
jgu.publisher.doi10.1007/s00726-022-03161-5de
jgu.organisation.rorhttps://ror.org/023b0x485-
jgu.subject.dfgLebenswissenschaftende
Appears in collections:DFG-491381577-H

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