Please use this identifier to cite or link to this item:
http://doi.org/10.25358/openscience-8326
Authors: | Paeslack, Nadja Mimmler, Maximilian Becker, Stefanie Gao, Zhenling Khuu, My Phung Mann, Amrit Malinarich, Frano Regen, Tommy Reinhardt, Christoph |
Title: | Microbiota-derived tryptophan metabolites in vascular inflammation and cardiovascular disease |
Online publication date: | 4-Jan-2023 |
Year of first publication: | 2022 |
Language: | english |
Abstract: | The essential amino acid tryptophan (Trp) is metabolized by gut commensals, yielding in compounds that affect innate immune cell functions directly, but also acting on the aryl hydrocarbon receptor (AHR), thus regulating the maintenance of group 3 innate lymphoid cells (ILCs), promoting T helper 17 (TH17) cell differentiation, and interleukin-22 production. In addition, microbiota-derived Trp metabolites have direct effects on the vascular endothelium, thus influencing the development of vascular inflammatory phenotypes. Indoxyl sulfate was demonstrated to promote vascular inflammation, whereas indole-3-propionic acid and indole-3-aldehyde had protective roles. Furthermore, there is increasing evidence for a contributory role of microbiota-derived indole-derivatives in blood pressure regulation and hypertension. Interestingly, there are indications for a role of the kynurenine pathway in atherosclerotic lesion development. Here, we provide an overview on the emerging role of gut commensals in the modulation of Trp metabolism and its influence in cardiovascular disease development. |
DDC: | 610 Medizin 610 Medical sciences |
Institution: | Johannes Gutenberg-Universität Mainz |
Department: | FB 04 Medizin |
Place: | Mainz |
ROR: | https://ror.org/023b0x485 |
DOI: | http://doi.org/10.25358/openscience-8326 |
Version: | Published version |
Publication type: | Zeitschriftenaufsatz |
License: | CC BY |
Information on rights of use: | https://creativecommons.org/licenses/by/4.0/ |
Journal: | Amino acids 54 |
Pages or article number: | 1339 1356 |
Publisher: | Springer |
Publisher place: | Wien u.a. |
Issue date: | 2022 |
ISSN: | 1438-2199 |
Publisher DOI: | 10.1007/s00726-022-03161-5 |
Appears in collections: | DFG-491381577-H |
Files in This Item:
File | Description | Size | Format | ||
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![]() | microbiotaderived_tryptophan_-20221117144742884.pdf | 1.36 MB | Adobe PDF | View/Open |